+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Systemic candidosis in silica-treated athymic and euthymic mice

Infection and Immunity 41(3): 902-907

Systemic candidosis in silica-treated athymic and euthymic mice

I.v. silica injections were used to assess the role of macrophages in the resistance of BALB/c nude and euthymic mice to systemic candidosis. Colony-forming units of Candida albicans in the kidneys, livers and spleens of saline- or silica-treated mice were enumerated at various times after inoculation with 104 viable yeast cells. The number of C. albicans organisms recovered from the kidneys of silica-treated euthymic mice was similar to the number recovered from saline-treated controls during the first 3 days of infection; at every assay period thereafter, the number of organisms recovered from the kidneys of silica-treated mice was dramatically reduced (100- to 1000-fold). Silica-treated nude mice were no more susceptible to systemic candidosis than were saline-injected nude mice. Silica treatment did not alter the ability of treated or control mice to clear C. albicans from the liver and spleen. Thus, macrophages play an important role in susceptibility to Candida infections.

(PDF 0-2 workdays service: $29.90)

Accession: 001260439

PMID: 6309672

Related references

The polycystic organ in senescent athymic nude mice and in euthymic mice. Folia Biologica 21(6): 382-386, 1975

Thermoregulation in athymic and euthymic hairless mice. Arnold, W, Koepf-Maier, P, Micheel, B Contributions to Oncology; Immunodeficient animals: Models for cancer research 1-11, 1996

Chemotherapy of chronic mucocutaneous candidosis and systemic candidosis treated by oral ketoconazole. Chemotherapie von Oberflachen , Organ und Systemmykosen I Deutsches Nizoral Symposium: 58-68, 1982

Pathogenesis of Campylobacter spp. in athymic and euthymic germfree mice. Infection and Immunity 53(2): 384-392, 1986

Comparative evaluation of the immune status of congenitally athymic and euthymic rat strains bred and maintained at different institutes: 1. Euthymic rats. Journal of Experimental Animal Science 35(1): 16-32, 1992

Molecular characterization of gut T cell precursors in euthymic and athymic mice. Advances in Experimental Medicine and Biology 495: 15-24, 2002

Pathogenesis of campylobacter spp for athymic and euthymic germ free mice. Abstracts of the Annual Meeting of the American Society for Microbiology 85: 51, 1985

Immune response of athymic and euthymic germfree mice to Campylobacter spp. Infection and Immunity 54(2): 339-346, 1986

Colonization and pathogenesis of Campylobacter spp. in athymic and euthymic germfree mice. Progress in Clinical and Biological Research 181: 199-202, 1985

Comparison of bone remodeling in euthymic and athymic nude mice. Journal Of Dental Researchec. Issue Mar: 147, 1988