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Systemic candidosis in silica-treated athymic and euthymic mice






Infection and Immunity 41(3): 902-907

Systemic candidosis in silica-treated athymic and euthymic mice

I.v. silica injections were used to assess the role of macrophages in the resistance of BALB/c nude and euthymic mice to systemic candidosis. Colony-forming units of Candida albicans in the kidneys, livers and spleens of saline- or silica-treated mice were enumerated at various times after inoculation with 104 viable yeast cells. The number of C. albicans organisms recovered from the kidneys of silica-treated euthymic mice was similar to the number recovered from saline-treated controls during the first 3 days of infection; at every assay period thereafter, the number of organisms recovered from the kidneys of silica-treated mice was dramatically reduced (100- to 1000-fold). Silica-treated nude mice were no more susceptible to systemic candidosis than were saline-injected nude mice. Silica treatment did not alter the ability of treated or control mice to clear C. albicans from the liver and spleen. Thus, macrophages play an important role in susceptibility to Candida infections.

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Accession: 001260439

PMID: 6309672



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