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Chapter 1,265

The effect of consumption of pyrrolizidine alkaloid containing plant Senecio jacobaea on iron and copper metabolism in the rat

Swick, R.A.; Cheeke, P.R.; Miranda, C.L.; Buhler, D.R.

Journal of Toxicology and Environmental Health 10(4/5): 757-768

1982


ISSN/ISBN: 1528-7394
Accession: 001264777

A diet containing 5% dried whole S. jacobaea given to rats for up to 8 weeks caused an increase in liver copper levels as well in less pronounced changes in iron, zinc and calcium levels. There was also a reduction in the incorporation of 59Fe into erythrocytes, suggesting impaired iron metabolism; this could be a secondary effect mediated by effects on copper distribution in tissues.

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