The effect of consumption of pyrrolizidine alkaloid containing plant Senecio jacobaea on iron and copper metabolism in the rat
Swick, R.A.; Cheeke, P.R.; Miranda, C.L.; Buhler, D.R.
Journal of Toxicology and Environmental Health 10(4/5): 757-768
A diet containing 5% dried whole S. jacobaea given to rats for up to 8 weeks caused an increase in liver copper levels as well in less pronounced changes in iron, zinc and calcium levels. There was also a reduction in the incorporation of 59Fe into erythrocytes, suggesting impaired iron metabolism; this could be a secondary effect mediated by effects on copper distribution in tissues.