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The effect of consumption of pyrrolizidine alkaloid containing plant Senecio jacobaea on iron and copper metabolism in the rat

Swick, R.A.; Cheeke, P.R.; Miranda, C.L.; Buhler, D.R.

Journal of Toxicology and Environmental Health 10(4/5): 757-768

1982

ISSN/ISBN: 1528-7394
Accession: 001264777
A diet containing 5% dried whole S. jacobaea given to rats for up to 8 weeks caused an increase in liver copper levels as well in less pronounced changes in iron, zinc and calcium levels. There was also a reduction in the incorporation of 59Fe into erythrocytes, suggesting impaired iron metabolism; this could be a secondary effect mediated by effects on copper distribution in tissues.

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Related References

Swick, R.A.; Cheeke, P.R.; Miranda, C.L.; Buhler, D.R. 1982: The effect of consumption of the pyrrolizidine alkaloid-containing plant Senecio jacobaea on iron and copper metabolism in the rat Journal of Toxicology and Environmental Health 10(4-5): 757-768
Swick, R.A.; Cheeke, P.R.; Miranda, L.; Buhler, D.R. 1982: Effect of consumption of the pyrrolizidine alkaloid containing plant senecio jacobaea on iron and copper metabolism in the rat Journal of Toxicology and Environmental Health 10(4-5): 757-768
Swick, R.A.; Cheeke, P.R.; Miranda, C.L.; Buhler, D.R. 1984: The effect of consumption of the pyrrolizidine alkaloid-containing plant Senecio jacobaea on iron and copper metabolism in the rat Journal of Environmental Pathology Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer 5(4-5): 59-69
Pieters, L.A.C.; Corthout, J.; Totte, J.; Vlietinck, A.J. 1985: Proton and carbon 13 spectroscopic analysis of the pyrrolizidine alkaloid content of senecio vulgaris senecio vernalis and senecio jacobaea Acta Agronomica Academiae Scientiarum Hungaricae 34(Suppl): 33
Buhler, D.R. 1981: Effect of feeding the pyrrolizidine alkaloid containing plant senecio jacobaea on the intra cellular distribution of metals in rat liver Federation Proceedings 40: 700
Kirk, H.; Vrieling, K.; Van Der Meijden, E.; Klinkhamer, P.G.L. 2010: Species by environment interactions affect pyrrolizidine alkaloid expression in Senecio jacobaea, Senecio aquaticus, and their hybrids Journal of Chemical Ecology 36(4): 378-387
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Macel, M.; Vrieling, K.; Klinkhamer, P.G.L. 2004: Variation in pyrrolizidine alkaloid patterns of Senecio jacobaea Phytochemistry 65(7): 865-873
W.H.G.Hol, K.V.andJ.A.vanV. 2003: Nutrients Decrease Pyrrolizidine Alkaloid Concentrations in Senecio jacobaea New Phytologist 158(1): 175-181
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Reed, R.L.; Buhler, D.R. 1988: The synthesis of 3H-putrescine and subsequent biosynthesis of 3H-jacobine, a pyrrolizidine alkaloid from Senecio Jacobaea Journal of Labelled Compounds and Radiopharmaceuticals 25(9): 1041-1048
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Jumai, A.; Rouzimaimaiti, R.; Zou, G.-A.; Aisa, H.A. 2021: Pyrrolizidine alkaloids and unusual millingtojanine A-B from Jacobaea vulgaris (syn. Senecio jacobaea L.) Phytochemistry 190: 112862
Reed, R.L.; Buhler, D.R. 1988: The synthesis of tritiated putrescine and subsequent biosynthesis of tritiated jacobine a pyrrolizidine alkaloid from senecio jacobaea Journal of Labelled Compounds and Radiopharmaceuticals 35(9): 1041-1048
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Reed, R.L.; Reed, B.M.; Buhler, D.R. 1985: Biosynthesis of radiolabeled pyrrolizidine alkaloids from Senecio jacobaea and Senecio vulgaris Planta Medica 51(5): 472
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