Blood flow and net amino acid uptake by the lactating mammary gland: effect of starvation

Vina, J.R.; Rodriguez, A.; Montoro, J.B.; Iradi, A.; Puertes, I.R.; Vina, J.

Biochemical Society Transactions 13(5): 876-877


ISSN/ISBN: 0300-5127
DOI: 10.1042/bst0130876
Accession: 001308958

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In lactating rats, starvation for 24 h produced a significant decrease in net amino acid uptake by the mammary gland. This was due to decreased blood flow to the gland (measured with 103Ru-labelled microspheres) and decreased arterial amino acid concn. The ratio of arteriovenous differences to arterial concn. of amino acids was decreased, showing that the decreased amino acid transport was not due to decreased arterial concn. alone. Net amino acid uptake was also decreased significantly by starvation for 6 h, mainly due to a decrease in arteriovenous differences across the mammary gland; blood flow to the gland was not significantly decreased. Neither starvation nor ketone bodies affected gamma -glutamyltransferase activity, indicating that effects are independent of the gamma -glutamyl cycle. Decreased arteriovenous differences were not accompanied by parallel changes in mammary gland amino acid concn., showing that amino acid utilization by the gland could be related to uptake.