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C-reactive protein for detection and follow-up of bacterial and fungal infections in severely neutropenic patients with acute leukaemia



C-reactive protein for detection and follow-up of bacterial and fungal infections in severely neutropenic patients with acute leukaemia



European Journal of Cancer and Clinical Oncology 21(5): 557-562



To evaluate the etiology of febrile episodes and to rationalize politics with antibiotics, C-reactive protein (CRP) was determined immunoturbidimetrically in 20 consecutive neutropenic adults with acute leukemia. They had 35 febrile episodes, 89% of which were infectious. Twenty percent of infections were fungal. A similar CRP response was seen both in bacterial and fungal infections. In 84% of infections, the peak value for CRP rose > 100 mg/l. Thirty-five apyrexial patients with acute leukemic and 20 healthy adults served as controls. Their CRP was < 10 mg/l in 87%. CRP proves most valuable in the follow-up of infections, the detection of infectious complications and the detection of possible invasive fungal infections. Although, relapse itself did not effect on CRP levels, extramedullary bone infiltration in 2 patients resulted in increased CRP production, which normalized with cytostatics only.

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Accession: 001311186

Download citation: RISBibTeXText

PMID: 4007021

DOI: 10.1016/0277-5379(85)90080-X


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