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CNS actions of calcitonin gene-related peptide on gastric acid secretion in conscious dogs



CNS actions of calcitonin gene-related peptide on gastric acid secretion in conscious dogs



American Journal of Physiology 250(6 Pt 1): G742-G748



To determine the mechanisms of action of calcitonin gene-related peptide (CGRP) in inhibiting gastric acid secretion, male beagle dogs with a chronic intracerebroventricular cannula and a gastric fistula were studied. Synthetic rat CGRP (10 pmol/kg to 10 nmol/kg) given intracerebroventricularly or intravenously significantly inhibited pentagastrin-stimulated gastric acid secretion.

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Accession: 001311271

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PMID: 3487252


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