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Calmodulin genes in trypanosomes are tandemly repeated and produce multiple mRNAs with a common 5' leader sequence



Calmodulin genes in trypanosomes are tandemly repeated and produce multiple mRNAs with a common 5' leader sequence



Proceedings of the National Academy of Sciences of the United States of America 82(12): 3998-4002



In Trypanosoma brucei gambiense, the Ca2+ binding protein calmodulin is encoded by 3 identical tandemly repeated genes. The transcripts of these genes consist of several RNA species similar in size. A 35-nucleotide spliced leader sequence is present at the 5' end of each mRNA but is not encoded by DNA contiguous to these genes. 2 different sites for the fusions of the leader to the mRNA were identified.

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Accession: 001311814

Download citation: RISBibTeXText

PMID: 3858856

DOI: 10.1073/pnas.82.12.3998


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