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Can albendazole reduce the risk of implantation of spilled protoscoleces? An animal study



Can albendazole reduce the risk of implantation of spilled protoscoleces? An animal study



Transactions of the Royal Society of Tropical Medicine and Hygiene 80(3): 481-484



Post-operative recurrence of hydatid disease occurs in approximately 10% of patients. The role of pre- or post-spillage chemotherapy with albendazole (10 mg/kg) was investigated in a gerbil model. All animals received approximately 5000 protoscoleces of ovine Echinococcus granulosus by intraperitoneal injection. Pre-spillage albendazole therapy did not protect against the development of cysts whilst a significant reduction in numbers of peritoneal cysts was seen in gerbils treated with albendazole 10 mg/kg for one week after inoculation. Two weeks therapy was no more effective. A very short course of albendazole treatment immediately following intraperitoneal 'spillage' of protoscoleces in a gerbil significantly reduced the number of cysts which developed. This finding may well be of clinical value.

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Accession: 001311936

Download citation: RISBibTeXText

PMID: 3798546

DOI: 10.1016/0035-9203(86)90352-4


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