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Coronavirus IBV: virus retaining spike glycopolypeptide S2 but not S1 is unable to induce virus-neutralizing or haemagglutination-inhibiting antibody, or induce chicken tracheal protection

Coronavirus IBV: virus retaining spike glycopolypeptide S2 but not S1 is unable to induce virus-neutralizing or haemagglutination-inhibiting antibody, or induce chicken tracheal protection

Journal of General Virology 67: 1435-1442

Avian infectious bronchitis virus (IBV), inactivated with propiolactone, induced partial protection of the trachea in up to 40% of chickens after one i/m inoculation 4-6 weeks before challenge. Retention of an intact tracheal ciliated epithelium 4 days after challenge was the criterion of protection. There was no correlation between protection and serum titres of virus-neutralizing (VN) and haemagglutination-inhibiting (HI) antibody, which were highest about 4 weeks after inoculation.

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Accession: 001327096

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PMID: 3014053

DOI: 10.1099/0022-1317-67-7-1435

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