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Differences in vitamin B6 status indicator responses between young and middle-aged women fed constant diets with two levels of vitamin B6

Differences in vitamin B6 status indicator responses between young and middle-aged women fed constant diets with two levels of vitamin B6

American Journal of Clinical Nutrition 42(2): 226-234

ISSN/ISBN: 0002-9165

PMID: 4025194

DOI: 10.1093/ajcn/42.2.226

The responses of adult women to two levels of vitamin B6, was conducted with five young and eight middle-aged subjects. A constant diet (2.3-2.4 mg vitamin B6 per day) was fed for four weeks followed by three weeks of the same diet supplemented with 8.0 mg pyridoxine. Plasma pyridoxal 5'-phosphate (PLP), plasma and urinary vitamin B6, and urinary 4-pyridoxic acid (4-PA) were determined. The older women had significantly lower plasma PLP, plasma and urinary vitamin B6 and slightly higher urinary 4-PA values on normal vitamin B6 intakes. With supplementation, only the difference in urinary total vitamin B6 remained significant. Tryptophan load tests revealed no significant between-group differences in xanthurenic acid or kynurenic acid excretion. These results demonstrate an age-related difference in vitamin B6 status indicators in women under controlled dietary intake of vitamin B6.

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Accession: 001336108

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