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Differential expression of alpha -fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line



Differential expression of alpha -fetoprotein genes on the inactive X chromosome in extraembryonic and somatic tissues of a transgenic mouse line



Nature, UK 319(6050): 224-226



The alpha -foetoprotein gene (Afp) is normally expressed at a high level in the visceral endoderm of the yolk sac and the liver of foetal mice, tissues in which the paternal X-chromosome is preferentially inactivated. In the present work, embryos were studied that were produced by matings involving or of a line of transgenic mice in which copies of an Afp "minigene" were integrated into the X-chromosome.

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