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Differential susceptibility of BALB/c sublines to diabetes induction by multi-dose streptozotocin treatment

Differential susceptibility of BALB/c sublines to diabetes induction by multi-dose streptozotocin treatment

Current Topics in Microbiology and Immunology 122: 78-85

The substrains BALB/cByJ and BALB/cJ both carry the H-2d allele, but differ at the Qa-2 and Qa-3 loci, and are histoincompatible in that they slowly reject reciprocal skin grafts. In the present work, administration of streptozotocin induced diabetes in BALB/cByJ but not in BALB/cJ Females of both substrains were resistant to induction of diabetes. The induction of diabetes in was associated with destruction of the insulin-producing beta -cells of the islets of Langerhans in the pancreas.

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Accession: 001336341

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PMID: 2931251

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