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Dilute-coat-color locus of mice: nucleotide sequence analysis of the d+2J and d+Ha revertant alleles



Dilute-coat-color locus of mice: nucleotide sequence analysis of the d+2J and d+Ha revertant alleles



Molecular and Cellular Biology 4(12): 2899-2904



The unstable dilute coat-color mutation (d) of DBA/2J mice is the result of integration of an ecotropic murine leukaemia virus into the genome. Molecular cloning and restriction enzyme analysis of the dilute allele, the viral preintegration site (+ allele), and of 2 independent dilute revertants (d+2J and d+Ha), suggested that reversion is due to virus excision occurring by homologous recombination involving the viral long terminal repeats.

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Accession: 001336692

Download citation: RISBibTeXText

PMID: 6098826

DOI: 10.1128/mcb.4.12.2899



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