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Diminished bone formation in experimental diabetes. Relationship to osteoid maturation and mineralization



Diminished bone formation in experimental diabetes. Relationship to osteoid maturation and mineralization



Diabetes 33(9): 825-831



Bone formation, mineralization and resorption were measured during 10 days using double-tetracycline labelling of bone in 18 control (C), 14 untreated diabetic (I-) and 16 insulin-treated diabetic (I+) rats. Diabetes was induced by injection of streptozotocin by vein, 90 mg/kg in citrate buffer. Bone and matrix (osteoid) formation and apposition were decreased by 50% from C values in I- rats, but were unchanged in I+ rats.

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Accession: 001336740

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PMID: 6381178

DOI: 10.2337/diab.33.9.825



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