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Effect of a cold stimulus on the synthesis of uncoupling protein in brown adipose tissue of rats and newborn rabbits


, : Effect of a cold stimulus on the synthesis of uncoupling protein in brown adipose tissue of rats and newborn rabbits. Bioscience Reports 5(1): 57-62

Rats are known to respond to a cold stimulus by increasing the activity and amount of the uncoupling protein in brown adipose tissue. A 48 h cold stimulus was found to increase the synthesis of uncoupling protein 3.8-fold in 4-5 wk old rats; no change was observed with newborn rabbits. The lack of response in the latter case may reflect a difference between rabbits and rats or that synthesis is already maximal in newborn rabbits.

Accession: 001342009

PMID: 3986309

DOI: 10.1007/bf01117441

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Arnold J.; Patel H.V.; Ridley R.G.; Freeman K.B., 1985: Effect of cold stimulus on the synthesis of uncoupling protein in brown adipose tissue of rats and newborn rabbits. Rats are known to respond to a cold stimulus by increasing the activity and amount of the uncoupling protein in brown adipose tissue. A 48 h cold stimulus was found to increase the synthesis of uncoupling protein 3.8-fold in 4-5 wk old rats; no ch...

Rozon D.K.; Harris W.H.; Gibbins A.M.V., 1989: Uncoupling protein and its messenger rna in brown adipose tissue of newborn rabbits. Guanosine diphosphate binding to the uncoupling protein of isolated mitochondria of brown adipose tissue in newborn rabbits was measured as an index of thermogenic activity. The binding was 0.281 .+-. 0.022 nmol GDP/mg mitochondrial protein at 1 d...

Rozon, D.K.; Harris, W.H.; Verrinder Gibbins, A.M., 1989: Uncoupling protein and its mRNA in brown adipose tissue of newborn rabbits. Guanosine diphosphate binding to the uncoupling protein of isolated mitochondria of brown adipose tissue in newborn rabbits was measured as an index of thermogenic activity. The binding was 0.281 +/- 0.022 nmol GDP/mg mitochondrial protein at 1 da...

Bing, C.; Pickavance, L.; Keith, J.S.; Frankish, H.M.; Wang, Q.; Trayhurn, P.; Williams, G., 1996: Acute cold exposure stimulates uncoupling protein synthesis in brown adipose tissue in lean, but not fatty Zucker rats. Clinical Science (London) 90(2): 16P-17P

Jakus, P.B.; Sipos, K.; Kispal, G.; Sandor, A., 2002: Opposite regulation of uncoupling protein 1 and uncoupling protein 3 in vivo in brown adipose tissue of cold-exposed rats. Earlier we reported a 14-fold increase of glycogen in the brown adipose tissue (BAT) in rats when the animals were placed back from cold to neutral temperature. To elucidate the mechanism, here we compared the level of glucose transporter 4 (GLUT4...

Reichling, S.; Ridley, R.G.; Patel, H.V.; Harley, C.B.; Freeman, K.B., 1987: Loss of brown adipose tissue uncoupling protein mRNA on deacclimation of cold-exposed rats. The effect of environmental temperature on the level of uncoupling protein mRNA from rat brown adipose tissue was examined using a cDNA probe. A 4.4 fold increase in the mRNA level was observed after 1 day exposure of rats to 6 degrees C, which wa...

Reichling S.; Ridley R.G.; Patel H.V.; Harley C.B.; Freeman K.B., 1987: Loss of brown adipose tissue uncoupling protein messenger rna on deacclimation of cold exposed rats. The effect of environmental temperature on the level of uncoupling protein mRNA from rat brown adipose tissue was examined using a cDNA probe. A 4.4 fold increase in the mRNA level was observed after 1 day exposure of rats to 6.degree. C, which wa...

Carmona, M.C.; Valmaseda, A.; Brun, S.; Viñas, O.; Mampel, T.; Iglesias, R.; Giralt, M.; Villarroya, F., 1998: Differential regulation of uncoupling protein-2 and uncoupling protein-3 gene expression in brown adipose tissue during development and cold exposure. The expression of the two novel uncoupling proteins genes, UCP2 and UCP3, is differentially regulated during prenatal maturation of brown adipose tissue in the mouse. UCP2 gene is expressed early in prenatal development, when neither UCP1 nor UCP3...

Denjean, F.; Lachuer, J.; Geloen, A.; Cohen Adad, F.; Moulin, C.; Barre, H.; Duchamp, C., 1999: Differential regulation of uncoupling protein-1, -2 and -3 gene expression by sympathetic innervation in brown adipose tissue of thermoneutral or cold-exposed rats. The control of uncoupling protein-1, -2 and -3 (UCP-1, UCP-2, UCP-3) mRNA levels by sympathetic innervation in Wistar rats was investigated by specific and sensitive reverse transcriptase polymerase chain reaction (RT-PCR) assays. In rats reared a...

Bouillaud F.; Ricquier D.; Mory G.; Thibault J., 1984: Increased level of messenger rna for the uncoupling protein in brown adipose tissue of rats during thermogenesis induced by cold exposure or norepinephrine infusion. In vitro translation was used to study the mRNA population from rat brown fat in 2 situations where the thermogenic activity of the tissue is stimulated. Both cold exposure of rats and the presence of pheochromocytoma result in marked alterations...