+ Translate

Effect of age on poly- and monoglutamyl folacin absorption in human subjects

, : Effect of age on poly- and monoglutamyl folacin absorption in human subjects. Journal of Nutrition 114(10): 1770-1776

Intestinal folacin absorption and mucosal conjugase activities were assessed in healthy male elderly (65-83 years) and young (20-29 years) human subjects. Luminal disappearance as measured simultaneously from the perfused jejunum of 3 mumol of both [3H]pteroylmonoglutamate [( 3H]PG-1) and pteroyl-[14C]glutamyl-hexaglutamate [( 14C]PG-7) as well as the urinary recovery of each isotope and mucosal conjugase activities were compared. Luminal disappearance of either [3H]PG-1 or [14C]PG-7 was not different for the two age groups (P greater than 0.05). The average (mean +/- SD) disappearance of [3H]PG-1 was 63 +/- 12% in the elderly and 67 +/- 6% in the young groups. In contrast, the disappearance of [14C]PG-7 averaged 51 +/- 6% in the elderly and 48 +/- 3% in the young group. Urinary recovery (percent in 48 hours) was not different for either isotope when the two age groups were compared (P greater than 0.05). The urinary recovery of 3H averaged 60 +/- 21% in the elderly and 59 +/- 13% in the young in contrast to 35 +/- 22% and 35 +/- 7% for 14C recovery in the elderly and young groups, respectively. Folacin conjugase activities measured at pH 6.5 and at pH 4.5 were not different between the groups (P greater than 0.05). The findings indicate that intestinal absorption of folacin and activity of folacin conjugases are not affected by the aging process.

(PDF 0-2 workdays service)

Accession: 001342292

PMID: 6548258

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Neuhaus, S.E.; Bailey, L.B.; Gregory, J.F.; Toth, J.P., 1994: Absorption of monoglutamyl and polyglutamyl folate at two stages of human gestation. FASEB Journal 8(4-5): A448

Gregory, J.F.; Bhandari, S.D.; Bailey, L.B.; Toth, J.P.; Baumgartner, T.G.; Cerda, J.J., 1991: Relative bioavailability of deuterium-labeled monoglutamyl and hexaglutamyl folates in human subjects. The bioavailability of orally administered mono- and polyglutamyl folates was examined in humans by using stable-isotope methods. [3',5'-2H2]Folic acid (d2-FA) and [3',5'-2H2]pteroylhexaglutamate (d2-PteGlu6) were prepared for...

Gregory, J.F.; Bhandari, S.D.; Bailey, L.B.; Toth, J.P.; Baumgartner, T.G.; Cerda, J.J., 1992: Relative bioavailability of deuterium-labeled monoglutamyl tetrahydrofolates and folic acid in human subjects. The bioavailability of orally administered monoglutamyl folic acid and various (6S)-tetrahydrofolates was examined in humans with stable-isotope methods. Folic acid (PteGlu), tetrahydrofolate (H4folate), 5-formyl-H4folate, 10-for-myl-h4folate, and...

Gregory J.F.; Bhandari S.D.; Bailey L.B.; Toth J.P.; Baumgartner T.G.; Cerda J.J., 1991: Bioavailability of deuterium labeled monoglutamyl forms of folic acid and tetrahydrofolates in human subjects. FASEB Journal 5(4): A915

Bailey L.B.; Cerda J.J.; Busby J.; Bloch B.S.; Vargas L.; Chandler C.J.; Halstead C.H., 1984: Effect of age on folacin absorption and conjugase enzyme activities in humans. Journal of the American Geriatrics Society 32(4 SUPPL): S21

Cooper, Ba, 1977: Physiology of absorption of monoglutamyl folates from the gastrointestinal tract. Folic Acid Biochemistry and Physiology In Relation To TheHuman Nutrition Requirement: ub 1977) 188-197

Zamierowski, M.M.; Wagner, C., 1977: Effect of folacin deficiency on folacin-binding proteins in the rat. The effect of experimental folacin deficiency on the uptake and distribution of radioactive folic acid in the rat was investigated. Less radioactivity was taken up by livers of deficient rats than controls 24 hours after intraperitoneal injection...

Celada, A.; Rudolf, H.; Donath, A., 1978: Effect of long-term administration of alcohol and of folacin deficiency on the absorption of iron. The influence of chronic ingestion of alcohol and artificially induced folic acid deficiency on iron absorption was measured in rabbits by whole-body counter. Chronic ingestion of alcohol did not modify iron absorption. Folic acid deficiency incre...

Halsted, C.H.; Reisenauer, A.M.; Shane, B.; Tamura, T., 1978: Availability of monoglutamyl and polyglutamyl folates in normal subjects and in patients with coeliac sprue. Intestinal folate absorption was assessed in 6 normal subjects and in 4 patients with celiac sprue who were studied before and after treatment by dietary gluten exclusion. Comparisons were made of the luminal disappearance from the perfused jejunu...

Cattan, D.B.laiche, J1; Zittoun, J1; Yvart, J., 1982: Effect of folate deficiency on vitamin B12 absorption Folic acid, folacin, cobalamin, old people, alcoholism. Annals of nutrition and metabolism 26(6): 367-373