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Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro






Science 231(4734): 156-159

Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro

Antibodies raised in mice immunized with several recombinant and synthetic peptides of the circumsporozoite protein of Plasmodium falciparum, were evaluated for protective activity in a human hepatocyte culture system. They exerted their protective effect against the parasite at 3 points: sporozoite attachment to the hepatocyte surface, entry, and subsequent intracellular development.

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Accession: 001342534

PMID: 3510455

DOI: 10.1126/science.3510455



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Effect of antibodies to recombinant and synthetic peptides on plasmodium falciparum sporozoites in vitro. Science (Washington D C) 231(4734): 156-159, 1986

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