+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro

Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro

Science 231(4734): 156-159

Antibodies raised in mice immunized with several recombinant and synthetic peptides of the circumsporozoite protein of Plasmodium falciparum, were evaluated for protective activity in a human hepatocyte culture system. They exerted their protective effect against the parasite at 3 points: sporozoite attachment to the hepatocyte surface, entry, and subsequent intracellular development.

(PDF same-day service: $19.90)

Accession: 001342534

Download citation: RISBibTeXText

PMID: 3510455

DOI: 10.1126/science.3510455

Related references

Effect of antibodies to recombinant and synthetic peptides on plasmodium falciparum sporozoites in vitro. Science (Washington D C) 231(4734): 156-159, 1986

Detection of antibodies to Plasmodium falciparum sporozoites by employing synthetic peptides. Parassitologia 28(2-3): 107-111, 1986

Detection of human antibodies against Plasmodium falciparum sporozoites using synthetic peptides. Journal of Clinical Microbiology 25(1): 91-96, 1987

Detection of human antibodies against Plasmodium falciparum and Plasmodium vivax sporozoites using synthetic peptides. Medical Science Research 18(18): 721-723, 1990

Synthetic peptides as antigens for the detection of humoral immunity to plasmodium falciparum sporozoites. Journal of Immunological Methods 93(1): 55-62, 1986

Comparative analysis of ELISAs employing repetitive peptides to detect antibodies to Plasmodium falciparum sporozoites. Bulletin of the World Health Organization 67(5): 515-523, 1989

A replicating adenovirus capsid display recombinant elicits antibodies against Plasmodium falciparum sporozoites in Aotus nancymaae monkeys. Infection and Immunity 83(1): 268-275, 2015

Human immune response in Plasmodium falciparum malaria. Synthetic peptides corresponding to known epitopes of the Pf155/RESA antigen induce production of parasite-specific antibodies in vitro. Journal of Immunology 147(7): 2295-2301, 1991

Inhibition of entry of Plasmodium falciparum and P. vivax sporozoites into cultured cells; an in vitro assay of protective antibodies. Journal of Immunology 132(2): 909-913, 1984

Molecular characterization of synthetic peptides and a recombinant protein of Plasmodium falciparum. American Journal of Tropical Medicine & Hygiene 61(3 SUPPL ): 198-199, Sept, 1999

Detection of antibodies to a 70 kDa Plasmodium falciparum exoantigen in malarious subjects using synthetic peptides. Tropical Medicine and Parasitology 44(1): 1-4, 1993

Responses of T cells from sensitized donors to recombinant and synthetic peptides corresponding to sequences of the Plasmodium falciparum SERP antigen. Immunology Letters 25(1-3): 149-153, 1990