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Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro


, : Effect of antibodies to recombinant and synthetic peptides on P. falciparum sporozoites in vitro. Science 231(4734): 156-159

Antibodies raised in mice immunized with several recombinant and synthetic peptides of the circumsporozoite protein of Plasmodium falciparum, were evaluated for protective activity in a human hepatocyte culture system. They exerted their protective effect against the parasite at 3 points: sporozoite attachment to the hepatocyte surface, entry, and subsequent intracellular development.

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Accession: 001342534

PMID: 3510455

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