+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Experimental development of resistance to decoquinate and robenidine in a multiple drug-resistant strain of Eimeria necatrix

Experimental development of resistance to decoquinate and robenidine in a multiple drug-resistant strain of Eimeria necatrix

Nihon Juigaku Zasshi. Japanese Journal of Veterinary Science 48(1): 69-74

A strain of Eimeria necatrix isolated in Miyazaki Prefecture, Japan, was examined for its sensitivity to 13 anticoccidials. Nine out of the 13 drugs were not efficacious, but three quinolone derivatives and robenidine was efficacious at their recommended dose-levels. Minimal effective concentration levels of decoquinate (one of the quinolone derivatives) and robenidine were approximately one-tenth of the recommended dose levels of manufacturers: 4 ppm for decoquinate and 4.125 ppm for robenidine. Therefore, we examined the reduction in sensitivity of this strain to these drugs by serially passaging in chickens fed the ration containing suboptimal dose-levels of these anticoccidials. The strain deteriorated the sensitivity to minimal effective concentration levels of decoquinate and robenidine after 50 and 10 passages, respectively. However, the strain was still highly sensitive to recommended-dose levels of decoquinate and robenidine after 50 and 40 passages, respectively.

(PDF emailed within 0-6 h: $19.90)

Accession: 001364006

Download citation: RISBibTeXText

PMID: 3959385

DOI: 10.1292/jvms1939.48.69

Related references

Drug resistance in coccidia: a robenidine-resistant strain of eimeria tenella. Canadian Journal of Comparative Medicine 41(4): 466-470, 1977

Development by genetic recombination of a line of Eimeria tenella resistant to robenidine, decoquinate and amprolium. Zeitschrift für Parasitenkunde 70(4): 437-441, 1984

Efficacy of decoquinate against eleven strains of Eimeria tenella and development of a decoquinate-resistant strain. Avian Diseases 15(2): 342-345, 1971

Drug-resistance in Eimeria tenella. I. The experimental development of a glycarbylamide-resistant strain. Jour Parasitol 47(6): 1001-1006, 1961

Drug resistance in Eimeria tenella II The experimental development of a zoalene-resistant strain. Jour Parasitol: 341-346, 1962

Drug resistance in Eimeria tenella. V. The experimental development of a nicarbazin-resistant strain. Journal of Parasitology 53(5): 930-932, 1967

Drug resistance in Eimeria tenella. VI. The experimental development of an Amprolium-resistant strain. Journal of Parasitology 54(3): 582-584, 1968

Drug Resistance In Eimeria Tenella. Iv. The Experimental Development Of A Nitrofurazone-Resistant Strain. Journal of Parasitology 49: 947-950, 1963

Section 1 || Drug Resistance in Eimeria tenella. II. The Experimental Development of a Zoalene-Resistant Strain. Journal of Parasitology 48(3): 341-346, 1962

Floor pen evaluations of the anti coccidial effects of decoquinate anti parasit on single and mixed species of chicken coccidia abstract eimeria tenella eimeria necatrix eimeria maxima eimeria brunetti eimeria acervulina. Poultry Science 47(5): 1685, 1968

Activity of decoquinate against eimeria necatrix and effect of the medication on development of immunity. Rivista di Parassitologia 37(1): 57-62, 1976

Eimeria tenella: experimental studies on the development of resistance to robenidine. Parasitology 73(3): 265-273, 1976

Titration of anticoccidial activity of salinomycin in six battery experiments with replacement pullets infected with single and mixed field strain isolates of eimeria necatrix eimeria acervulina eimeria mivati eimeria tenella eimeria maxima and eimeria brunetti. Poultry Science 65(SUPPL 1): 194, 1986

The development of a precocious strain of Eimeria necatrix. Journal of Eukaryotic Microbiology 51(2): 18A, 2004

Eimeria tenella: development of resistance to arprinocid and decoquinate in the chicken. Research in Veterinary Science 38(2): 226-230, 1985