EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Experimental zinc deficiency in guinea-pigs: clinical signs and some haematological studies



Experimental zinc deficiency in guinea-pigs: clinical signs and some haematological studies



British Journal of Nutrition 54(2): 421-428



1. Thirty-three male, weanling guinea-pigs were divided into two groups. One group was fed on a zinc-deficient (ZnD) diet (1.25 mg Zn/kg diet) for 45 d and then divided into two subgroups: subgroup 1 continued on diet ZnD while subgroup 2 was fed on a Zn-repleted diet (100 mg Zn/kg diet) for 15 d. The second group was fed on a Zn-adequate diet (50 mg Zn/kg diet) for 60 d. 2. Zn deficiency could be produced within 21 d as evidenced by clinical signs and reduction in serum Zn concentration. 3. Clinical signs exhibited were listlessness, scabby lesions on skin near the foot pads, mild alopecia and a reduction in body-weight gain. No effect was observed on food intake. 4. Significant decreases in packed cell volume and total leucocyte count from 48 d onwards accompanied by absolute lymphocytopenia and relative neutrophilia were observed. 5. Supplementation of Zn in the Zn-repleted group resulted in marked, though incomplete, improvement with regard to serum Zn concentration, clinical signs and haematological changes.

(PDF emailed within 0-6 h: $19.90)

Accession: 001364413

Download citation: RISBibTeXText

PMID: 4063328

DOI: 10.1079/bjn19850127



Related references

Effect of foot and mouth disease virus infection in zinc deficient guinea pigs: clinical signs and haematological changes. Indian Journal of Veterinary Pathology 24(2): 125-126, 2000

Studies on the pathology of experimental zinc deficiency in guinea-pigs. Journal of Comparative Pathology 98(4): 405-413, 1988

Zinc deficiency in guinea pigs impaired platelet aggregation and other signs. Federation Proceedings 41(3): ABSTRACT 82, 1982

Production and reversal of the neuromuscular pathology and related signs of zinc deficiency in guinea pigs. Journal of Nutrition 119(2): 196-201, 1989

Experimental zinc deficiency in guinea-pigs: biochemical changes. British Journal of Nutrition 55(3): 613-620, 1986

Experimental salmonellosis in guinea-pigs: haematological and biochemical studies. Veterinary Research Communications 23(7): 415-424, 1999

Experimental selenium toxicity in guinea pigs: haematological studies. Annals of Nutrition & Metabolism 33(6): 347-353, 1989

Effect of experimental zinc deficiency on thyroid gland in guinea-pigs. Annals of Nutrition & Metabolism 41(6): 376-381, 1997

Studies on experimental Jembrana disease in Bali cattle. II. Clinical signs and haematological changes. Journal of Comparative Pathology 103(1): 61-71, 1990

Effect of experimental zinc deficiency and repletion on some immunological variables in guinea-pigs. British Journal of Nutrition 59(1): 149-154, 1988

Effect of experimental zinc deficiency on immunological responses in Salmonella-infected guinea-pigs. Journal of Comparative Pathology 123(1): 1-6, 2000

Effect of experimental zinc deficiency on protein and feed efficiency ratios in guinea-pigs. Indian Journal of Nutrition and Dietetics 29(11): 342-344, 1992

Studies on clinical signs and some haematological parameters in experimental acute intoxication with the triazole fungicide triticonazole in swine. Bulgarian Journal of Veterinary Medicine 7(2): 97-105, 2004

Effect of experimental zinc deficiency and repletion on sodium, potassium, copper and iron concentrations in guinea-pigs. British Journal of Nutrition 62(2): 407-414, 1989