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Expression of CTL-defined, AKR/Gross retrovirus-associated tumor antigens by normal spleen cells: control by Fv-1, H-2, and proviral genes and effect on antiviral CTL generation



Expression of CTL-defined, AKR/Gross retrovirus-associated tumor antigens by normal spleen cells: control by Fv-1, H-2, and proviral genes and effect on antiviral CTL generation



Journal of Immunology 136(1): 308-312



The expression of cytotoxic T-cell-defined viral antigens by normal spleen cells was studied in relation to possible gene dosage effects by H-2 as well as Fv-1 and other virus-related genes (including proviral structural loci) by comparing a panel of congenic and F1 mice. These experiments indicated that the quantitative level of expression of cytotoxic T-cell-defined viral antigens was primarily controlled by the Fv-1 genotype.

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Accession: 001364628

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PMID: 2999246



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