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Extension of the Haldane-Muller principle of mutation load with application for estimating a possible range of relative evolution rate

Extension of the Haldane-Muller principle of mutation load with application for estimating a possible range of relative evolution rate

Genetical Research 46(1): 75-84

The principle of mutation load was generalised so as to be applicable to cases of strong and very weak selection with any time variation. It was proved that in an infinite asexual haploid population, the av. Malthusian parameter m of a population, the evolution rate v, and the total mutation rate mu satisfy the relation delta m/ delta mu = v/ mu -1, so long as each Malthusian parameter is independent of mu. This was found to be also true in a diploid population under genic selection.

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Accession: 001364765

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PMID: 4065567

DOI: 10.1017/s0016672300022461

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