+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Extension of the Haldane-Muller principle of mutation load with application for estimating a possible range of relative evolution rate



Extension of the Haldane-Muller principle of mutation load with application for estimating a possible range of relative evolution rate



Genetical Research 46(1): 75-84



The principle of mutation load was generalised so as to be applicable to cases of strong and very weak selection with any time variation. It was proved that in an infinite asexual haploid population, the av. Malthusian parameter m of a population, the evolution rate v, and the total mutation rate mu satisfy the relation delta m/ delta mu = v/ mu -1, so long as each Malthusian parameter is independent of mu. This was found to be also true in a diploid population under genic selection.

(PDF emailed within 0-6 h: $19.90)

Accession: 001364765

Download citation: RISBibTeXText

PMID: 4065567

DOI: 10.1017/s0016672300022461


Related references

Optimum mutation rate and degree of dominance as determined by the principle of minimum genetic load. Jour Genet 57(1): 21-34, 1960

Mutation rates in globin genes: the genetic load and Haldane's dilemma. Progress in Nucleic Acid Research and Molecular Biology 19: 205-220, 1976

Haldane and the mutation rate. Journal of Genetics 71(3): 81-87, 1992

The application of the principle of partial pressure of gases to Haldane's method of stage decompression. Journal of Hygiene 43(6): 409-410, 1944

Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7. Genetics 184(1): 221-232, 2010

10. The concept of mutation component of genetic diseases and its application for estimating the responsiveness of mendelian diseases to an increase in mutation rate. Annals of the Icrp 29(3-4): 87-95, 2000

Haldane and the first estimates of the human mutation rate. Journal of Genetics 83(3): 231-233, 2005

The mutation load under tetrasomic inheritance and its consequences for the evolution of the selfing rate in autotetraploid species. Genetical Research 74(1): 31-42, 1999

"Haldane's dilemma" and the rate of evolution. Nature 219(5159): 1114-1116, 1968

'Haldane's dilemma' and the rate of evolution. Annals of Human Genetics 33(3): 245-249, 1970

On the genetics and mutation rate of retinoblastoma With some general remarks on the methods of estimating the mutation rate in man. 1954

The validation of a method for estimating the work load and heat load from continuous recording of heart rate. Travail Humain 35(1): 131-142, 1972

Assay for estimating total bacterial load: relative qPCR normalisation of bacterial load with associated clinical implications. Diagnostic Microbiology and Infectious Disease 83(1): 1-6, 2016

Mutation-selection balance: ancestry, load, and maximum principle. Theoretical Population Biology 62(1): 9-46, 2002