Gamma-glutamyl-amino acids as signals for the hormonal regulation of amino acid uptake by the mammary gland of the lactating rat

Viña, J.R.; Puertes, I.R.; Montoro, J.B.; Saez, G.T.; Viña, J.

Biology of the Neonate 48(4): 250-256


ISSN/ISBN: 0006-3126
PMID: 2865983
DOI: 10.1159/000242178
Accession: 001373512

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In lactating rats injected intraperitoneally with the gonadotropin release inhibitor Danazol, mammary gland amino acid uptake and gamma -glutamyltransferase activity were decreased compared with controls. Treatment with a mixture of luteinizing hormone and follicle-stimulating hormone restored values to normal, but treatment with oestradiol or oestradiol + progesterone was only partially effective. In rats previously treated with bromocriptine, (which decreases prolactin release, gamma -glutamyltransferase activity and mammary amino acid uptake), gamma -glutamyl-glutamine injection stimulated amino acid uptake by the mammary gland. It is suggested that gamma -glutamyl amino acids, which are products of gamma -glutamyltransferase, may act as signals that activate amino acid transport systems.