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Gas chromatographic determination and mass spectrometric confirmation of malathion in milk and blood



Gas chromatographic determination and mass spectrometric confirmation of malathion in milk and blood



Journal of Agricultural and Food Chemistry 34(1): 87-88



A rapid and sensitive method for the determination of malathion and malaoxon in milk and plasma has been developed. Following a simple extraction and cleanup procedure malathion and malaoxon were analyzed by gas-liquid chromatography (GLC) equipped with a phosphorus-specific detector and a glass column (2.5 m .times. 3 mm i.d.) packed with 3% SE-30 on 80-100-mesh Chromosorb W AW DMCS. For quantification the internal standard technique was used with bromophos as the internal standard. All compounds eluted within 5 min. Confirmation of the identities was obtained by gas-liquid chromatography-mass spectrometry (GLC-MS) with a flexible quartz capillary column (25 m .times. 0.20-0.21 mm i.d.) coated with SE-54. Recoveries ranged from 85 to 98%. The detection limits of malathion and malaoxon in milk were 0.002 and 0.02 ppm, respectively, and in plasma 0.004 and 0.04 ppm, respectively. Linearity of the response was observed in the concentration range studied (linear regression coefficient, r = 0.99994, in the concentration range 0.002-0.2 ppm).

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Accession: 001373556

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DOI: 10.1021/jf00067a023


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