Is the insulin resistance of patients with noninsulin-dependent diabetes mellitus secondary to insulin deficiency?

Reaven, G. M.; Chen, Y. D.; Moore, J. G.; Hollenbeck, C. B.

Defects in insulin secretion and action have been documented in patients with noninsulin-dependent diabetes (NIDD), leading to the suggestion that fasting hyperglycaemia and insulin resistance in NIDD are secondary to insulin deficiency. To test this hypothesis, insulin secretion (plasma insulin response to oral glucose) and insulin action (insulin clamp) were estimated in 25 patients with NIDD.