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Ivermectin therapy for infection in mice with second-stage larvae of Toxocara canis. Efficacy in relation to the timing of treatment

, : Ivermectin therapy for infection in mice with second-stage larvae of Toxocara canis. Efficacy in relation to the timing of treatment. Annali della Facolta di Medicina Veterinaria di Pisa 1985; 37: 141-145

Ivermectin given parenterally to mice at a dose of 80 mg/kg prevented colonization of the brain with T. canis if given 12 or 24 hours after administration of embryonated eggs by stomach tube. Ivermectin reduced but did not prevent brain infection if given 5 or 2 days before or at the time of infection, and was ineffective if given 15 or 10 days before or 72 hours after infection.

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