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Ivermectin therapy for infection in mice with second-stage larvae of Toxocara canis. Efficacy in relation to the timing of treatment


, : Ivermectin therapy for infection in mice with second-stage larvae of Toxocara canis. Efficacy in relation to the timing of treatment. Annali della Facolta di Medicina Veterinaria di Pisa 1985; 37: 141-145

Ivermectin given parenterally to mice at a dose of 80 mg/kg prevented colonization of the brain with T. canis if given 12 or 24 hours after administration of embryonated eggs by stomach tube. Ivermectin reduced but did not prevent brain infection if given 5 or 2 days before or at the time of infection, and was ineffective if given 15 or 10 days before or 72 hours after infection.


Accession: 001398307

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Related references

Casarosa, L.; Ghelardoni, E.; Lugetti, G.; Magi, M.; Bigini, M.; Sbrana, L., 1983: Therapeutic efficacy of ivermectin in mice experimentally infected with second-stage larvae of Toxocara canis. One-month-old mice were given orally 2000 embryonated T. canis eggs and 24 hours later injected subcutaneously with ivermectin at 80 mg/kg body weight. PM examination 7 or 20 days after infection showed that ivermectin prevented larval migration t...

Casarosa, L.; Lugetti, G., 1982: Ivermectin in infection of mice by Toxocara canis L2 larvae. Prelminary note. Mice experimentally infected with 2000 T. canis eggs were treated with 80 mg/kg body weight of ivermectin 24 h post-infection. Necropsies on day 7 and day 20 of infection showed that migration of larvae in the liver and lungs was arrested and no e...

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