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Ivermectin therapy for infection in mice with second-stage larvae of Toxocara canis. Efficacy in relation to the timing of treatment

, : Ivermectin therapy for infection in mice with second-stage larvae of Toxocara canis. Efficacy in relation to the timing of treatment. Annali della Facolta di Medicina Veterinaria di Pisa 1985; 37: 141-145

Ivermectin given parenterally to mice at a dose of 80 mg/kg prevented colonization of the brain with T. canis if given 12 or 24 hours after administration of embryonated eggs by stomach tube. Ivermectin reduced but did not prevent brain infection if given 5 or 2 days before or at the time of infection, and was ineffective if given 15 or 10 days before or 72 hours after infection.

Accession: 001398307

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Related references

Casarosa, L.; Ghelardoni, E.; Lugetti, G.; Magi, M.; Bigini, M.; Sbrana, L., 1983: Therapeutic efficacy of ivermectin in mice experimentally infected with second-stage larvae of Toxocara canis. One-month-old mice were given orally 2000 embryonated T. canis eggs and 24 hours later injected subcutaneously with ivermectin at 80 mg/kg body weight. PM examination 7 or 20 days after infection showed that ivermectin prevented larval migration t...

Casarosa, L.; Lugetti, G., 1982: Ivermectin in infection of mice by Toxocara canis L2 larvae. Prelminary note. Mice experimentally infected with 2000 T. canis eggs were treated with 80 mg/kg body weight of ivermectin 24 h post-infection. Necropsies on day 7 and day 20 of infection showed that migration of larvae in the liver and lungs was arrested and no e...

Macchioni, G.; Marconcini, A., 1967: Experimental infection of mice by subcutaneous inoculation of 2nd-stage larvae of Toxocara canis and application of the Baermann apparatus with peptide digestion for the isolation of ascarid larvae from tissue. A method of infecting mice subcutaneously with 2nd-stage larvae of Toxocara canis and isolation of larvae from host tissues by pepsin digestion are briefly described. The advantages of these techniques are discussed.

Casarosa, L.; Papini, R.; Magi, M.; Mancianti, F.; Malloggi, M.; Messina, N.; Sassetti, M.; Lugetti, G.; Cerreta, S., 1987: Plurivisceral migratory activity in mice of Toxocara canis L2 larvae treated in vitro with ivermectin. T. canis L2 larvae cultured in vitro for 24 hours at 37 degrees C in Hank's saline with gentamicin and 15 mg/ml ivermectin were injected subcutaneously into mice. Compared with control larvae not treated with ivermectin, only a few migrated i...

Pal, B.; Mitra, S.K.; Sasmal, N.K.; Biswas, D., 1995: Comparative efficacy of piperazine, ivermectin and albendazole against experimentally induced Toxocara canis infection in pups. Therapeutic efficacy of piperazine, ivermectin (at different doses) and albendazole against Toxocara canis infection of pups was evaluated by epg and worm count. From the study it is concluded that albendazole 20 mg/kg.b.wt. for 3 consecutive days...

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Abo Shehada M.N., 1982: The effect of some anti helminthics on the 2nd stage larvae of toxocara canis in mice. Molecular & Biochemical Parasitology (SUPPL): 490-491