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Ketoconazole treatment of disseminated paracoccidioidomycosis in the rat


, : Ketoconazole treatment of disseminated paracoccidioidomycosis in the rat. Revista Argentina de Micologia 8(1): 6-8

Wistar rats were given ketoconazole orally for 4 weeks at 40 or 80 mg/kg/day starting 3 days before challenge inoculation with Paracoccidioides brasiliensis. On autopsy, granulomas of the lungs were found in 12 of 15 animals of the untreated control, in 3 of 5 rats given ketoconazole at 40 mg/kg/day and in 2 of 16 rats treated at 80 mg/kg/day.


Accession: 001398822

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Related references

Hahn, R.Christine.; Morato Conceição, Y.Teresinha.; Santos, N.Lara.; Ferreira, J.Fialho.; Hamdan, Júnia.Soares., 2003: Disseminated paracoccidioidomycosis: correlation between clinical and in vitro resistance to ketoconazole and trimethoprim sulphamethoxazole. The present study relates to a case of subacute multifocal paracoccidioidomycosis where the upper intestinal tract is involved. The involvement of the upper digestive tract is uncommon. The recommended therapeutic treatment plans and the difficult...

Cucé, L.C.; Wroclawski, E.L.; Sampaio, S.A., 1981: Treatment of paracoccidioidomycosis with ketoconazole. On oral administration of ketoconazole at 400 mg/day for 30 days and then at 200 mg/day for 60 days skin lesions cicatrized in 3-4 weeks in 32 of 36 patients and in 6-7 weeks in the rest. Mycological tests were negative in all cases at the end of...

Marcondes, J.; Meira, D.A.; Mendes, R.P.; Pereira, P.C.M.; Barraviera, B.; Mota, N.G. da S.; Morceli, J., 1984: Evaluation of ketoconazole treatment of paracoccidioidomycosis. In the treatment of 12 patients with chronic and systemic lesions due to Paracoccidioides brasiliensis, ketoconazole was administered orally once daily at 400 mg for the 1st month and at 200 mg for the next 17 months. The clinical picture, X-ray o...

Negroni, R.; Robles, A.M.; Arechavala, A.; Tuculet, M.A.; Galimberti, R., 1980: Ketoconazole in the treatment of paracoccidioidomycosis and histoplasmosis. Ketoconazole was successful in achieving clinical and radiological cure in 37 (88.09%) of 42 patients with Paracoccidioides brasiliensis infection and in 22 (91.6%) of 24 patients with Histoplasma capsulatum infection. Serological tests (complemen...

Restrepo, A.; Stevens, D.A.; Gómez, I.; Leiderman, E.; Angel, R.; Fuentes, J.; Arana, A.; Mejía, G.; Vanegas, A.C.; Robledo, M., 1980: Ketoconazole: a new drug for the treatment of paracoccidioidomycosis. Ketoconazole therapy (200 mg/day orally) was successful for 13 patients with pulmonary, mucosal and skin lesions caused by Paracoccidioides brasiliensis. No adverse effects were observed.

Marcondes, J.; Meira, D.A.; Mendes, R.P.; Pereira, P.C.; Barraviera, B.; Mota, N.G.; Morceli, J., 1984: Evaluation of the treatment of paracoccidioidomycosis with ketoconazole. Revista do Instituto de Medicina Tropical de Sao Paulo 26(2): 113-121

Lima, N. dos S.; Valle, A.C.F. do, 1987: Ketoconazole in paracoccidioidomycosis with long follow-up after treatment. A total of 10 patients with Paracoccidioides brasiliensis infection, 8 with the chronic disseminated form (adult type) and 2 with the subacute lymphatic form (juvenile type), were treated with oral ketoconazole for periods ranging from 3.5 to 28 m...

Restrepo M.A.; Gomez, I.; Cano, L.E.; Arango, M.D.; Gutierrez, F.; Sarun, A.; Robledo, M.A., 1983: Treatment of paracoccidioidomycosis with ketoconazole: a three-year experience. Ketoconazole (200 mg/day orally for 6 months) was used in the treatment of 38 patients with active Paracoccidioides brasiliensis infection. None of the patients worsened during therapy, 1 was unchanged, 5 had minor improvement, 30 had major improv...

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