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Ketoconazole: an orally effective antifungal agent. Mechanism of action, pharmacology, clinical efficacy and adverse effects






PharmacoTherapy 4(4): 199-204

Ketoconazole: an orally effective antifungal agent. Mechanism of action, pharmacology, clinical efficacy and adverse effects

Following a review it is concluded that symptomatic drug-induced hepatitis occurs in approx. 1 in 12 000 patients and that this side effect and potential effects on testosterone and cortisol synthesis may limit the use of ketoconazole to deep fungal infections and severe recalcitrant superficial infections of the skin.

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Accession: 001398831

PMID: 6091064



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