Section 2
Chapter 1,408

Metabolic fate of 4- (o-benzylphenoxy) -N-methylbutylamine hydrochloride (MCI-2016) . VI. Foeto-placental transfer and excretion into milk

Iida, S.; Inokuchi, T.; Sato, T.

Pharmacometrics 31(1): 211-215


ISSN/ISBN: 0300-8533
Accession: 001407527

Passage of [14C]4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (14C-MCI-2016) into foetuses and milk were studied in pregnant and lactating rats, resp., following oral administration at 50 mg/kg. When 14C-MCI-2016 was administered orally to lactating rats, radioactivity in milk increased gradually, reached a peak (about 4.7 micro g/g) at 24 h, and then decreased gradually until 48 h after dosing. Radioactivity in milk was 1.2-39 times that in maternal blood between 6 and 48 h after dosing.

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