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Pancreatic growth and enzyme profiles in weanling rats with normophagic hypothalamic obesity


Canadian Journal of Physiology and Pharmacology 62(12): 1533-1538
Pancreatic growth and enzyme profiles in weanling rats with normophagic hypothalamic obesity
Weanling male rats with ventromedial hypothalamic lesions (VMNL) and sham-operated controls were killed 1, 2, 4, and 5 weeks after operation. The VMNL rats developed normophagic hypothalamic obesity in the presence of normal bodyweight and reduced linear growth. In VMNL and control rats, pancreatic weight and protein content increased with time but were lower in lesioned rats. Pancreatic DNA content was arrested in VMNL rats and remained so during the remainder of the experiment.


Accession: 001424182

PMID: 6085027

DOI: 10.1139/y84-254



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