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Regulation of sympathetic activity in lean and obese Zucker (fa/fa) rats

Regulation of sympathetic activity in lean and obese Zucker (fa/fa) rats

American Journal of Physiology 249(3 Pt 1): E299-E305

ISSN/ISBN: 0002-9513

PMID: 4037080

Norepinephrine concentration and turnover (estimated by the time-dependent loss of tissue orepinephrine specific activity) were reduced in the brown adipose tissue (AT) of obese Zucker rats but were normal in the heart. After adaptation to a 4 degrees C environment for 7 days, brown AT norepinephrine turnover was increased to similar values in lean and obese rats. After overfeeding with sucrose brown AT norepinephrine turnover increased in lean rats but was unaffected in obese rats.

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Accession: 001446159

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