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Severe clinical disease induced in cattle persistently infected with noncytopathic bovine viral diarrhea virus by superinfection with cytopathic bovine viral diarrhea virus

Bolin, S.R.; McClurkin, A.W.; Cutlip, R.C.; Coria, M.F.

American Journal of Veterinary Research 46(3): 573-576

1985


ISSN/ISBN: 0002-9645
PMID: 2986494
Accession: 001458903

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Eight healthy cattle that were persistently infected with noncytopathic bovine viral diarrhea virus (BVDV) were inoculated with cell culture fluids that contained noncytopathic or cytopathic BVDV. A severe disease occurred after inoculation with cytopathic BVDV. The clinical signs, lesions, and immune response were consistent with those of clinical BVDV infections.

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