The distension stimulus to gastric acid secretion in the isolated mouse stomach

Davison, J.S.; Najafi-Farashah, A.

Canadian Journal of Physiology and Pharmacology 63(12): 1533-1536

1985


ISSN/ISBN: 0008-4212
PMID: 3830352
DOI: 10.1139/y85-252
Accession: 001481222

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Abstract
Distension of the isolated mouse stomach stimulated gastric acid secretion. Atropine, cimetidine or proglumide antagonized the actions of cholinomimetics, histamine and gastrin, respectively. Those antagonists and the nerve-blocking agent tetrodotoxin were without effect on basal secretion or distension-stimulated secretion. It is concluded that in the isolated mouse stomach neither basal secretion nor secretion evoked by distension involve the release of any of the established physiological secretagogues or the activation of intramural nerves.