EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

The effect of carbonic anhydrase inhibition on breathing movements and electrocortical activity in fetal sheep



The effect of carbonic anhydrase inhibition on breathing movements and electrocortical activity in fetal sheep



Respiration Physiology 61(3): 327-334



Fetal breathing movements (FBM) indicated by repetitive negative intrathoracic pressures and biparietal electrocorticograms (ECoG) were recorded from 8 fetal sheep for 3 h before (control) and 3 h after the administration of a carbonic anhydrase inhibitor, acetazolamide. FBM and the low voltage (LV) ECoG state occurred 36 .+-. 5% (SEM) and 60 .+-. 3% of the control period, respectively. Virtually no FBM occurred during high voltage (HV) ECoG while in 57 .+-. 6% of the LV state the fetuses were making FBM. The peak magnitude of the negative intrathoracic (tracheal) pressure deflections was 4 .+-. 1 Torr. Following acetazolamide the incidence of FBM rose to 53 .+-. 4% (P < 0.01) but there was no significant change in the incidence of the LV state (58 .+-. 3%). Most of the increase in the incidence of FBM remained confined to periods of LV ECoG activity so that an increased proportion of this state (88 .+-. 2%, P < 0.001) was occupied with respiratory efforts. The amplitude of the FBM also increased to 8 .+-. 1 Torr (P < 0.05). The increased incidence and depth of FBM is most likely due to an elevated hydrogen ion concentration and differs from a fetal respiratory acidosis induced by increasing the inspired CO2 fraction to the ewe in that the respiratory stimulation induced by acetazolamide is not associated with an increased incidence of the permissive LV ECoG state.

Accession: 001482175

Download citation: RISBibTeXText

PMID: 3933069

DOI: 10.1016/0034-5687(85)90075-1

Download PDF Full Text: The effect of carbonic anhydrase inhibition on breathing movements and electrocortical activity in fetal sheep



Related references

Effect of morphine on fetal electrocortical activity and breathing movements in fetal sheep. Developmental Pharmacology and Therapeutics 8(2): 115-128, 1985

Effect of unilateral left pneumonectomy on fetal breathing movements and electrocortical activity in sheep. Pediatric Research 31(4 PART 2): 309A, 1992

The effects of raising intracranial pressure on breathing movements, eye movements and electrocortical activity in fetal sheep. Journal of Developmental Physiology 8(2): 105-116, 1986

The central effects of trh on the breathing movements and electrocortical activity of the fetal sheep. Pediatric Research 23(1): 72-75, 1988

Effects of moderate hypoxia on fetal electrocortical activity, eye movements, and breathing activity in sheep. Journal of Developmental Physiology 8(6): 411-419, 1986

Effects of bilateral total pneumonectomy on breathing movements and electrocortical activity in fetal sheep. Pediatric Research 31(4 PART 2): 359A, 1992

Effects of increased core temperature on breathing movements and electrocortical activity in fetal sheep. Journal of Developmental Physiology 10(6): 513-523, 1988

Electrocortical activity electroocular activity and breathing movements in fetal sheep with prolonged and graded hypoxemia. American Journal of Obstetrics & Gynecology 167(2): 553-558, 1992

The central effects of thyrotropin-releasing hormone on the breathing movements and electrocortical activity of the fetal sheep. Pediatric Research 23(1): 72-75, 1988

Effects of glucose concentration on fetal breathing movements and electrocortical activity in fetal lambs. American Journal of Obstetrics and Gynecology 142(6 Pt 1): 678-683, 1982

Effect of reducing uteroplacental blood flow on movements and on electrocortical activity of fetal sheep. Gynecologic and Obstetric Investigation 23(1): 34-39, 1987

Effects of clonidine on breathing movements and electrocortical activity in the fetal lamb. American Journal of Obstetrics & Gynecology 163(2): 661-668, 1990

Effect of lithium on enzyme activity of carbonic anhydrase (4.2.1.1): indirect inhibition of carbonic anhydrase in the oviduct of the hen. Archiv fur Geflugelkunde 64(2): 82-84, 2000

Effect of inhibition of prostaglandin synthesis on breathing movements and pulmonary blood flow in fetal sheep. Journal of Applied Physiology 78(2): 531-538, 1995

Effects of a prolonged infusion of a placental extract on breathing and electrocortical activity in the fetal sheep. Pediatric Research 41(4 PART 2): 300A, 1997