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The measurement in vivo of the rate of unesterified cholesterol exchange between rat plasma and erythrocytes

The measurement in vivo of the rate of unesterified cholesterol exchange between rat plasma and erythrocytes

Biochimica et Biophysica Acta 834(3): 331-335

In order to investigate the rate of unesterified cholesterol exchange between plasma and erythrocytes in vivo, cholesterol labeling in rats was achieved in 1 of the following ways: i.v. injection of cholesterol-labeled erythrocytes, s.c. injection of labeled acetate, feeding of labeled cholesterol. The specific activity of the unesterified cholesterol was measured at intervals up to 24 h and a kinetic analysis of the data was performed. It assumes that both the cholesterol in the erythrocytes and the unesterified cholesterol in the plasma were homogeneous pools. The rate constants obtained for the movements of unesterified cholesterol from erythrocytes to plasma and from plasma to erythrocytes were not significantly different in the 3 labeling conditions (mean values: 0.26 and 1.5 h-1, respectively).

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Accession: 001489398

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PMID: 3995070

DOI: 10.1016/0005-2760(85)90006-2

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