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The mode of antifungal action of tolnaftate



The mode of antifungal action of tolnaftate



Journal of Medical and Veterinary Mycology 24(2): 155-160



The anti-dermatophyte agent tolnaftate was compared with the allylamine antifungal compounds naftifine and terbinafine. Tolnaftate was shown to inhibit sterol biosynthesis at the level of squalene epoxidation and squalene was shown to accumulate in dermatophytes grown in its presence. Biochemical studies in whole and broken cells supported this conclusion and showed that the compound was active against squalene epoxidation in broken Candida albicans cells, but was much less potent against whole cells. These results suggested there was a barrier to penetration in these yeasts.

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Accession: 001489664

Download citation: RISBibTeXText

PMID: 3522841

DOI: 10.1080/02681218680000221


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