+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The mode of antifungal action of tolnaftate

The mode of antifungal action of tolnaftate

Journal of Medical and Veterinary Mycology 24(2): 155-160

The anti-dermatophyte agent tolnaftate was compared with the allylamine antifungal compounds naftifine and terbinafine. Tolnaftate was shown to inhibit sterol biosynthesis at the level of squalene epoxidation and squalene was shown to accumulate in dermatophytes grown in its presence. Biochemical studies in whole and broken cells supported this conclusion and showed that the compound was active against squalene epoxidation in broken Candida albicans cells, but was much less potent against whole cells. These results suggested there was a barrier to penetration in these yeasts.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 001489664

Download citation: RISBibTeXText

PMID: 3522841

DOI: 10.1080/02681218680000221

Related references

Studies on the mode of action of tolnaftate in Microsporum gypseum. Journal of Medical and Veterinary Mycology 29(1): 45-52, 1991

Antifungal activity of 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone against Candida albicans: evidence for the antifungal mode of action. Antonie van Leeuwenhoek 108(5): 1047-1057, 2015

A new antifungal agent--tolnaftate. Journal of the Indian Medical Association 54(7): 320-322, 1970

Topical antifungal formulation containing tolnaftate. Official Gazette of the United States Patent & Trademark Office Patents 1235(3), 2000

Mode of action of antifungal antibiotics I Action on amphotericin B on the respiratory metabolism of Candida albicans. Ann Inst Pasteur: 9-484, 1960

Tolnaftate, a Potent Topical Antifungal Agent. Archives of Dermatology 91: 372-376, 1965

Antifungal Properties of Tolnaftate in Vitro and in Vivo. Antimicrobial Agents and ChemoTherapy 10: 595-601, 1964

Erythrasma. Response to tolnaftate, an antifungal medication. Archives of Dermatology 97(2): 173-175, 1968

Tolnaftate (tinactin), a new topical antifungal agent. Canadian Medical Association Journal 93(19): 1004-1005, 1965

Clinical and comparative evaluation of "Tolnaftate" as an antifungal agent in the U.A.R. Journal of the Egyptian Medical Association 49(2): 178-184, 1966

Comparative in vitro and in vivo antifungal activity of tolnaftate and various undecylenates. Journal of Pharmaceutical Sciences 69(6): 739-741, 1980

Comparative in vitro and in vivo antifungal activity of tolnaftate and various undecylenates: a rebuttal. Journal of Pharmaceutical Sciences 69(6): 741-742, 1980

Combination effect of salicylic acid on antifungal activity of tolnaftate preparation (ZM-589). Japanese Journal of Medical Mycology 34(1): 27-34, 1993

Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrobial Agents & Chemotherapy 29(5): 858-860, 1986

Nonplanar property study of antifungal agent tolnaftate-spectroscopic approach. Spectrochimica Acta. Part A Molecular and Biomolecular Spectroscopy 79(5): 993, 2011