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Viral haemorrhagic septicaemia in rainbow trout: attempt to relate interferon production, antibody synthesis and structure of the virus with the mechanism of virulence


Annales de l' Institut Pasteur/Virologie 136E(1): 13-26
Viral haemorrhagic septicaemia in rainbow trout: attempt to relate interferon production, antibody synthesis and structure of the virus with the mechanism of virulence
Rainbow trout infected with either pathogenic virus strains or attenuated variants were compared for virus multiplication, interferon (IFN) synthesis and neutralizing antibody (NAb) production. Both the attenuated and pathogenic virus strains were similarly low IFN inducers during the 1st cycle of multiplication of the virus in spleen and/or kidney; IFN production then increased in fish infected with the virulent virus. No difference could be evidenced when the virus strains were compared in cell cultures for their sensitivity to circulating IFN. Late protection against a challenge was mediated by Nab, but Nab synthesis was inversely proportional to the virulence of this virus strain. Glycosyl residues on the G polypeptides of the different strains were also compared: the modifications observed were not related to virulence.

Accession: 001507654

DOI: 10.1016/S0769-2617(85)80109-X

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