EurekaMag.com logo
+ Translate

Viral haemorrhagic septicaemia in rainbow trout: attempt to relate interferon production, antibody synthesis and structure of the virus with the mechanism of virulence


, : Viral haemorrhagic septicaemia in rainbow trout: attempt to relate interferon production, antibody synthesis and structure of the virus with the mechanism of virulence. Annales de l' Institut Pasteur/Virologie 136E(1): 13-26

Rainbow trout infected with either pathogenic virus strains or attenuated variants were compared for virus multiplication, interferon (IFN) synthesis and neutralizing antibody (NAb) production. Both the attenuated and pathogenic virus strains were similarly low IFN inducers during the 1st cycle of multiplication of the virus in spleen and/or kidney; IFN production then increased in fish infected with the virulent virus. No difference could be evidenced when the virus strains were compared in cell cultures for their sensitivity to circulating IFN. Late protection against a challenge was mediated by Nab, but Nab synthesis was inversely proportional to the virulence of this virus strain. Glycosyl residues on the G polypeptides of the different strains were also compared: the modifications observed were not related to virulence.

Accession: 001507654

DOI: 10.1016/S0769-2617(85)80109-X

Download PDF Full Text: Viral haemorrhagic septicaemia in rainbow trout: attempt to relate interferon production, antibody synthesis and structure of the virus with the mechanism of virulence


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Bernard J.; Bearzotti L.B.rre M.; D.K.nkelin P., 1985: Viral hemorrhagic septicemia in rainbow trout attempt to relate interferon production antibody synthesis and structure of the virus with the mechanism of virulence. Rainbow trout infected with either pathogenic virus strains or attenuated variants were compared for virus multiplication, interferon (IFN) synthesis and neutralizing antibody (NAb) production. Both the attenuated and pathogenic virus strains were...

Dorson, M.; Torhy, C.; D.K.nkelin, P., 1994: Viral haemorrhagic septicaemia virus multiplication and interferon production in rainbow trout and in rainbow trout X brook trout hybrids. Rainbow trout (Oncorhynchus mykiss) susceptible to Viral Haemorrhagic Septicaemia (VHS) Virus type 1 and rainbow trout times brook trout (Salvelinus fontinalis) triploid hybrids were challenged with VHSV by either immersion or i.p. injection of th...

Campbell, S.; McBeath, A.; Secombes, C.; Snow, M.; Collet, B., 2011: Interferon response following infection with genetically similar isolates of viral haemorrhagic septicaemia virus (VHSV) exhibiting contrasting virulence in rainbow trout. Isolates of viral haemorrhagic septicaemia virus (VHSV) were identified which are genetically similar yet, based on their isolation history were considered likely to differ in virulence in juvenile rainbow trout. An experimental infection study wa...

Ito, T.; Kurita, J.; Mori, K-ichiro.; Olesen, N.J., 2016: Virulence of viral haemorrhagic septicaemia virus (VHSV) genotype III in rainbow trout. In general, viral haemorrhagic septicaemia virus (VHSV) isolates from marine fish species in European waters (genotypes GIb, GII and GIII) are non- to low virulent in rainbow trout. However, a VHSV isolation was made in 2007 from a disease outbrea...

Renault, T.; Torchy, C.; Kinkelin, P. de, 1991: Spectrophotometric method for titration of trout interferon, and its application to rainbow trout fry experimentally infected with viral haemorrhagic septicaemia virus. The activity of a reference preparation of rainbow trout circulating interferon (IFN), induced by experimental infection of fish with viral haemorrhagic septicaemia virus, was detected on the basis of its non-specific protective effect for RTG-2 c...

Campbell, S.; Collet, B.; Einer-Jensen, K.; Secombes, C.J.; Snow, M., 2010: Identifying potential virulence determinants in viral haemorrhagic septicaemia virus (VHSV) for rainbow trout. We identified viral haemorrhagic septicaemia virus (VHSV) isolates classified within Genotype Ib which are genetically similar (>99.4% glycoprotein amino acid identity) yet, based on their isolation history, were suspected to differ in virulenc...

Boudinot, P.; Salhi, S.; Blanco, M.; Benmansour, A., 2001: Viral haemorrhagic septicaemia virus induces vig-2, a new interferon-responsive gene in rainbow trout. The induction and the genomic organization of a new probable interferon-responsive gene in rainbow trout was studied. A new transcript (vig-2) induced by viral haemorrhagic septicaemia virus(VHSV) in rainbow trout leukocytes was identified in the...

Habashi, Y.; Schlotfeldt, H.J.; Frost, J.W., 1975: Production of antisera against the virus of viral haemorrhagic septicaemia (VHS) of rainbow trout. Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 22(8): 666-672

Habashi, Y.; Schlotfeldt, H.J.; Frost, J.W., 1975: Production of antisera against the virus of viral haemorrhagic septicaemia (VHS) of rainbow trout. Immunization of rabbits by the intravenous route at short intervals with infective tissue culture supernatant fluid resulted in titres up to 1:6090, at which dilution the serum neutralized 100 TCID50 of virus. Large amounts of antiserum were obtai...

Snow, M.; Cunningham, C.O., 2000: Virulence and nucleotide sequence analysis of marine viral haemorrhagic septicaemia virus following in vivo passage in rainbow trout Onchorhynchus mykiss. A marine isolate of viral haemorrhagic septicaemia virus (VHSV) (860/94) was passaged in triplicate through sequential batches of rainbow trout via an intra-peritoneal infection route, without amplification in tissue culture. Following 5 passages,...