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A comparison of the response of Dipetalonema viteae and Brugia pahangi adult worms to antifilarial agents in vitro



A comparison of the response of Dipetalonema viteae and Brugia pahangi adult worms to antifilarial agents in vitro



Tropical Medicine and Parasitology 37(4): 375-380



The drug responses of Dipetalonema viteae and B. pahangi under various culture conditions were evaluated. B. pahangi female worms proved to be more susceptible to CGP 6140 (4-nitro-4'-(N-methyl)piperazinyl thiocarbonylidodiphenylamine), CGP 20376 (N-(2-tert-butyl-5-methoxy-benzothiazol-6-yl)dithiocarbonic acid 5-(1-carboxyethyl)-ether) and amoscanate when glucose availability was restricted. This increased potency may be related to effects on glycogen metabolism by CGP 20376 and amoscanate.

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Accession: 001514124

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PMID: 3563317


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