A new male hypogonadism mutant rat (hgn/hgn) : concentrations of testosterone (T) , luteinizing hormone (LH) , and follicle-stimulating hormone (FSH) in the serum and the responsiveness of accessory sex organs to exogenous T, FSH, human chorionic gonadotropin, and luteinizing hormone-releasing hormone
Hakamata, Y.; Kikukawa, K.; Kamei, T.; Suzuki, K.; Taya, K.; Sasamoto, S.
Biology of Reproduction 38(5): 1145-1153
ISSN/ISBN: 0006-3363 PMID: 3136809 DOI: 10.1095/biolreprod38.5.1145
Male hypogonadism in a newly found mutant rat is controlled by the hgn gene, an autosomal recessive. To study the aetiology of the condition, serum concentrations of testosterone, LH and FSH were measured, and the responsiveness of the urogenital organs, hypothalamus and pituitary gland to testosterone (1 mg/kg body weight, subcutaneously for 7 days), FSH (0.3 IU/kg for 7 days), HCG (40 IU/kg subcutaneously for 7 days), and LHRH (0.5 or 5.0 micro g/kg for 7 days) were tested. Treatment with testosterone increased the weights of all of the accessory sex organs, whereas treatment with FSH, HCG or LHRH did not.