Section 2
Chapter 1,517

A new male hypogonadism mutant rat (hgn/hgn) : concentrations of testosterone (T) , luteinizing hormone (LH) , and follicle-stimulating hormone (FSH) in the serum and the responsiveness of accessory sex organs to exogenous T, FSH, human chorionic gonadotropin, and luteinizing hormone-releasing hormone

Hakamata, Y.; Kikukawa, K.; Kamei, T.; Suzuki, K.; Taya, K.; Sasamoto, S.

Biology of Reproduction 38(5): 1145-1153


ISSN/ISBN: 0006-3363
PMID: 3136809
DOI: 10.1095/biolreprod38.5.1145
Accession: 001516638

Download citation:  

Male hypogonadism in a newly found mutant rat is controlled by the hgn gene, an autosomal recessive. To study the aetiology of the condition, serum concentrations of testosterone, LH and FSH were measured, and the responsiveness of the urogenital organs, hypothalamus and pituitary gland to testosterone (1 mg/kg body weight, subcutaneously for 7 days), FSH (0.3 IU/kg for 7 days), HCG (40 IU/kg subcutaneously for 7 days), and LHRH (0.5 or 5.0 micro g/kg for 7 days) were tested. Treatment with testosterone increased the weights of all of the accessory sex organs, whereas treatment with FSH, HCG or LHRH did not.

Full Text Article emailed within 0-6 h: $19.90