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Atrial natriuretic factor and vasopressin during dehydration and rehydration in rats

Atrial natriuretic factor and vasopressin during dehydration and rehydration in rats

American Journal of Physiology 251(4 Pt 1): E497-E501

To determine the effect of water deprivation (mixed volume and osmotic stimulus) on the secretion of atrial natriuretic factor (ANF) and arginine vasopressin (AVP), plasma immunoreactive ANF (IR-ANF), and plasma AVP were measured in normal conscious Sprague-Dawley rats, IR-ANF was decreased to 19.9 .+-. 3.6 pg/ml (24 h dehydration), 9.8 .+-. 2.5 pg/ml (48 h dehydration), and undetectable level (72 h dehydration) from the control level of 62.4 .+-. 2.4 pg/ml. These decreases were accompanied by significant increase in plasma AVP, serum Na+, osmolality (osm), and hematocrit, (Hct). In animals deprived of water for 3 days the secretion of ANF and AVP was monitored at seven time points during the 1st h after voluntary rehydration with tap water. After rehydration, IR-ANF was elevated dramatically within 3 min and gradually for up to 1 h after water was offered: AVP decreased within 3 min of rehydration and stayed at the water-repleted level during the next 1 h. Na+, osm, and Hct did not change until 15, 9, and 30 min after rehydration, respectively. The rapid mofidications in plasma IR-ANF and AVP were accompanied by a transient but significant increase in arterial blood pressure for up to 15 min after water consumption. These results indicate that oropharyngeal-gastric stimuli contribute to the release of both ANF and AVP.

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Accession: 001533603

Download citation: RISBibTeXText

PMID: 2945441

DOI: 10.1152/ajpendo.1986.251.4.E497

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