EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Atrial natriuretic factor and vasopressin during dehydration and rehydration in rats



Atrial natriuretic factor and vasopressin during dehydration and rehydration in rats



American Journal of Physiology 251(4 Pt 1): E497-E501



To determine the effect of water deprivation (mixed volume and osmotic stimulus) on the secretion of atrial natriuretic factor (ANF) and arginine vasopressin (AVP), plasma immunoreactive ANF (IR-ANF), and plasma AVP were measured in normal conscious Sprague-Dawley rats, IR-ANF was decreased to 19.9 .+-. 3.6 pg/ml (24 h dehydration), 9.8 .+-. 2.5 pg/ml (48 h dehydration), and undetectable level (72 h dehydration) from the control level of 62.4 .+-. 2.4 pg/ml. These decreases were accompanied by significant increase in plasma AVP, serum Na+, osmolality (osm), and hematocrit, (Hct). In animals deprived of water for 3 days the secretion of ANF and AVP was monitored at seven time points during the 1st h after voluntary rehydration with tap water. After rehydration, IR-ANF was elevated dramatically within 3 min and gradually for up to 1 h after water was offered: AVP decreased within 3 min of rehydration and stayed at the water-repleted level during the next 1 h. Na+, osm, and Hct did not change until 15, 9, and 30 min after rehydration, respectively. The rapid mofidications in plasma IR-ANF and AVP were accompanied by a transient but significant increase in arterial blood pressure for up to 15 min after water consumption. These results indicate that oropharyngeal-gastric stimuli contribute to the release of both ANF and AVP.

(PDF emailed within 0-6 h: $19.90)

Accession: 001533603

Download citation: RISBibTeXText

PMID: 2945441

DOI: 10.1152/ajpendo.1986.251.4.E497



Related references

Atrial natriuretic factor inhibits dehydration and hemorrhage-induced vasopressin release. Neuroendocrinology 40(3): 277-279, 1985

Dehydration-induced alterations in rat brain vasopressin and atrial natriuretic factor immunoreactivity. Endocrinology 117(3): 1279-1281, 1985

Plasma atrial natriuretic factor and vasopressin during thermal dehydration in supine posture. Travaux Scientifiques des Chercheurs du Service de Sante des Armees (10): 131-132, 1989

Effect of atrial natriuretic factor on plasma vasopressin in conscious rats. Peptides (New York) 7(6): 989-994, 1986

Dehydration-induced changes in the secretion of atrial natriuretic factor in Brattleboro rats: effect of water-drinking. Neuroscience Letters 67(2): 203-207, 1986

Antihypertensive effect of synthetic atrial natriuretic factor in vasopressin-infused rats. Japanese Circulation Journal 50(11): 1185-1190, 1986

Renal and endocrine effects of atrial natriuretic factor anf in hypertensive rats with and without endogenous vasopressin avp. Journal of Endocrinology 131(SUPPL), 1991

The relationship in humans between atrial natriuretic peptide and arginine vasopressin during dehydration. Federation Proceedings: 528, 1986

Atrial natriuretic factor enhances vasopressin-induced bradycardia in normotensive (WKY) but not in spontaneously hypertensive (SHR) rats. European Journal of Clinical Investigation 18(6): 568-574, 1988

Intraventricular atrial natriuretic factor reduces osmotically induced vasopressin release in conscious rats. Society for Neuroscience Abstracts 12(1): 447, 1986

Hemodynamic and renal effects of atrial natriuretic factor in portal hypertensive rats. Potentiation by Phe-Ile-Orn-vasopressin. Journal of Pharmacology and Experimental Therapeutics 246(3): 941-945, 1988

Plasma atrial natriuretic peptide and vasopressin during thermal dehydration in supine posture. Acta Physiologica Scandinavica 141(2): 227-230, 1991

Chronic effect of synthetic atrial natriuretic factor in rats made hypertensive by sustained infusion of vasopressin. Brenner, B M And J H Laragh (Ed ) American Society Of Hypertension Symposium Series, Vol 1 Biologically Active Atrial Peptides Xxvii+626p Raven Press: New York, New York, Usa Illus 519-523, 1987

Plasma vasopressin and renal response following atrial natriuretic factor infusion in saline loaded anesthetized rats. Clinical Research: 116a, 1986

Vasopressin gene expression in the paraventricular nucleus of spontaneously hypertensive rats in response to dehydration and rehydration. Neuroendocrinology 60(SUPPL 1): 24, 1994