EurekaMag.com logo
+ Site Statistics
References:
54,215,046
Abstracts:
30,230,908
PMIDs:
28,215,208
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Atrial natriuretic peptide levels during acute and chronic saline loading in conscious dogs



Atrial natriuretic peptide levels during acute and chronic saline loading in conscious dogs



American Journal of Physiology 251(3 Pt 2): R499-R503



The purpose of the present study was to determine if acute and chronic increases in sodium intake by isotonic saline infusion are accompanied by changes in plasma concentrations of atrial natriuretic peptide (PANP). Acute saline loading (5% body wt) over a 30-min period in seven conscious chronically instrumented dogs produced a significant increase in PANP (48 .+-. 5 to 119 .+-. 24 pg/ml, P < 0.05). However, chronic and progressive increments of sodium intake from 5 to 75 to 300 meq/day for 7 days, each by isotonic saline infusion, where examined in the same group of dogs and had no significant effect on PANP. PANP's were 37 .+-. 7, 39 .+-. 8, and 33 .+-. 5 pg/ml when sodium intake was changed from 5 to 75 to 300 meq/day, respectively. The increase of sodium intake from 5 to 75 meq/day produced decreases of plasma renin activity (PRA) (2.5 .+-. 0.5 to 1.5 .+-. 0.4 ng angiotensin I .cntdot. ml-1 .cntdot. h-1, P < 0.05), plasma aldosterone concentration (PAC) (19.3 .+-. 5.4 to 2.9 .+-. 0.4 pg/ml, P < 0.05), and urinary excretion of prostaglandin E2 (760 .+-. 131 to 320 .+-. 58 pg/min, P < 0.05). Further increase of sodium intake to 300 meq/day induced decreases of PRA and PAC to undetectable levels and an increase of urinary excretion of 6-ketoprostaglandin F1.alpha. (649 .+-. 95 to 1,056 .+-. 148 pg/min, P < 0.05). Before the completion of the study, sodium intake was decreased from 300 to 75 meq/day. This reduction did not alter PANP but did return PRA, PAC, and urinary excretion of prostaglandin F1.alpha. to values comparable to those seen before sodium intake was increased from 75 to 300 meq/day. In summary, acute sodium loading significantly increased PANP. However, despite marked alterations in PRA, PAC, and urinary excretion of prostaglandins, chronic sodium loading had no long-term effect of PANP.

(PDF emailed within 1 workday: $29.90)

Accession: 001533608

Download citation: RISBibTeXText

PMID: 2944396



Related references

Plasma atrial natriuretic peptide levels during acute and chronic saline volume expansion in conscious dogs. Kidney International 29(1): 406, 1986

Metoclopramide does not affect renal function and atrial natriuretic peptide release in response to acute saline loading in conscious rats. Pharmacology 48(2): 93-99, 1994

The role of atrial natriuretic peptide in the natriuretic response to acute saline loading. Puschett, J B International Congress Series; Diuretics IV: Chemistry, pharmacology and clinical applications: 669-674, 1993

Plasma levels of atrial natriuretic peptide anp in shr during acute and chronic salt loading. Journal of Cardiovascular Pharmacology 8(6): 1310, 1986

Bilateral atrial appendectomy abolishes increased plasma atrial natriuretic peptide release and blunts sodium and water excretion during volume loading in conscious dogs. Circulation Research 70(4): 724-732, 1992

Physiologic infusions of atrial natriuretic peptide anp potentiate the responses to hypertonic saline infusion in conscious dogs. FASEB Journal 2(4): ABSTRACT 1345, 1988

Acute saline loading in normal and bilaterally atrial-resected conscious dogs. American Journal of Physiology 255(1 Pt 2): H144-H152, 1988

Response of atrial natriuretic peptide to acute saline loading in essential hypertension. American Journal of Physiology 255(6 Pt 2): F1085-F1090, 1988

Hypotensive effects of chronic infusions of atrial natriuretic peptide in conscious dogs. Hypertension (Dallas) 7(5): 846, 1985

Cocaine increases circulating levels of atrial natriuretic peptide and pro atrial natriuretic peptide N-terminal fragment in conscious rats. European Journal Of Pharmacology. 304(1-3): 55-62, 1996

N-terminal atrial natriuretic peptide and atrial natriuretic peptide in human plasma: investigation of plasma levels and molecular circulating form(s) using radioimmunoassays for pro-atrial natriuretic peptide (31-67), pro-atrial natriuretic peptide (1-30) and atrial natriuretic peptide (99-126). Clinical Science 87(3): 311-317, 1994

N-Terminal atrial natriuretic peptide and atrial natriuretic peptide in human plasma Investigation of plasma levels and molecular circulating form using radioimmunoassays for pro-atrial natriuretic peptide , pro-atrial natriuretic peptide and atrial natriuretic peptide. Clinical Science (London) 87(3): 311-317, 1994

Elevated left heart pressure causes increases in plasma levels of atrial natriuretic peptide in conscious dogs. Journal of Physiology (Cambridge) 371: 247P, 1986