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Autacoids: their release and possible role in the pathogenesis of African trypanosomiasis

Autacoids: their release and possible role in the pathogenesis of African trypanosomiasis

Immunology and pathogenesis of trypanosomiasis: 45-66

The current state of knowledge on autacoids released in trypanosomiasis in man, cattle and laboratory animals, the mechanisms of their release and their possible implication to the pathogenesis of the disease are considered in this review under the following headings: the kallikrein-kinin system in trypanosomiasis; histamine and trypanosomiasis; 5-hydroxytryptamin and trypanosomiasis; catecholamines and trypanosomiasis; other biologically active substances (lysosomal enzymes, products of complement activation and fibrin-fibrinogen degradation products); pathological consequences of autacoid release; the pathogenesis of trypanosomiasis.

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