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Babesia bovis: vaccination trial with a dominant immunodiffusion antigen in splenectomised calves


Zeitschrift fur Parasitenkunde 72(6): 715-722
Babesia bovis: vaccination trial with a dominant immunodiffusion antigen in splenectomised calves
The dominant immunodiffusion antigen of Babesia bovis was prepared for the lysate of infected erythrocytes by cation exchange chromatogrpahy, gel filtration and preparative native acrylamide electrophoresis. It was seemingly free of other babesial antigens and tested as a vaccine. In vaccinated calves, compared to controls, there was a delay in parasitaemia and at times a statistically significant difference in parasitaemia and at times a statistically significant difference in parasite numbers. However, the vaccinates showed little difference in pathophysiological parameters or survival rates from the controls. It was concluded that serodominance cannot necessarily be correlated with protection.

Accession: 001534429

PMID: 3099492

DOI: 10.1007/bf00925093

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