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Contribution to our knowledge on the mode of action of monensin

Contribution to our knowledge on the mode of action of monensin

Advances in protozoological research Proceedings of the 1st International Conference of Hungary on protozoology, and Memorial Session for Jozsef Gelei 1885-1952, Budapest, Hungary, 3-6 September 1985: 441-444

Incubation of freshly hatched Eimeria tenella sporozoites in 0.1 micro g/ml monensin in phosphate buffered saline for 2 min. reduced their ability to subsequently penetrate cells in chick embryo cultures by up to 3 fold and substantially reduced the number of schizonts produced in the first generation, as compared to untreated control cultures. At the same concentration, monensin added to trypsin and bile excystation solution did not affect the number of sporozoites excysting.

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