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Control of Toxocara canis in puppies: a comparison of screening techniques and evaluation of a dosing programme


, : Control of Toxocara canis in puppies: a comparison of screening techniques and evaluation of a dosing programme. Journal of Veterinary Pharmacology and Therapeutics 10(1): 23-29

Conventional chemoprophylaxis of canine toxocariasis is based upon the treatment of young puppies. It is proposed that physiological considerations and the complexity of the host-parasite relationship in the case of Toxocara canis demand that anthelmintic evaluation should properly be conducted in such animals rather than in adolescent or adult dogs. A screening model using the critical trial technique in early weaned pups gave variable results even with compounds known to be of high efficacy in older dogs. Circumstantial evidence suggested that this inconsistency may be related to the rate of passage of ingesta through such young animals. More satisfactory results were obtained by pairing unweaned naturally infected puppies by weight and sex and treating one of each pair with the test compound. Natural in utero and transmammary infection was found to give fairly consistent worm-burdens within each litter and a good indication of efficacy could therefore be estimated by comparing post mortem worm-counts. On this basis, the apparent efficacies of pyrantel pamoate (5 mg kg-1) and piperazine (100 mg kg-1) were found to be 83.5 and 82.5%, respectively. This method was extended to evaluate a prophylactic programme in which anthelmintic therapy was given to pups when aged 10, 20 and 30 days. Intestinal T. canis populations were reduced, at 35 days of age, by between 94.2% and 98.0%. This programme increased overall weight gains between 10 and 30 days of age by 18% (P < 0.05) although there was great variation between litters. The biggest response was observed in male pups between 20 and 30 days old.

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Accession: 001554394

PMID: 3586119

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Related references

Jacobs D.E., 1987: Control of toxocara canis in puppies a comparison of screening techniques and evaluation of a dosing program. Conventional chemoprophylaxis of canine toxocariasis is based upon the treatment of young puppies. It is proposed that physiological considerations and the complexity of the host-parasite relationship in the case of Toxocara canis demand that anth...

Payne, P.A.; Ridley, R.K., 1999: Strategic use of ivermectin during pregnancy to control Toxocara canis in greyhound puppies. Twenty-one greyhound bitches were bred (Day 0) and housed throughout their pregnancies on three greyhound breeding farms in Kansas. These dogs were assigned randomly to one of four treatment groups. Group A dogs (6) were given ivermectin subcutane...

Payne, P.A.; Ridley, R.K., 1999: Strategic use of ivermectin during pregnancy to control toxocara canis in greyhound puppies. Twenty-one greyhound bitches were bred (Day 0) and housed throughout their pregnancies on three greyhound breeding farms in Kansas. These dogs were assigned randomly to one of four treatment groups. Group A dogs (6) were given ivermectin subcutane...

Soilev, C.; Seleva, R.; Todorov, T.; Vutova, K., 1984: Prevalence of Toxocara canis in puppies in Bulgaria. The intestinal contents of 112 mongrel puppies from the Sofia and Vidin area in Bulgaria were examined in 1976-81. T. canis was present in 88.8% of town dogs, 96.2% of strays and 100% of dogs from villages and animal farms. Of 109 puppies examined...

Lloyd, S.; Wijesundera, M.K.; Soulsby, E.J., 1991: Intestinal changes in puppies infected with Toxocara canis. Small intestinal histopathology and absorption were examined in Beagle puppies infected with either a moderate or a low burden of Toxocara canis. Infection with T. canis significantly reduced absorption of xylose, but only slightly delayed absorpt...

Soilev C.; Seleva R.; Todorov T.; Vutova K., 1984: Spread of toxocara canis among puppies in bulgaria. Angewandte Parasitologie 25(2): 93-96

Soilev, C.; Seleva, R.; Todorov, T.; Vutova, K., 1984: Distribution of Toxocara canis in puppies in Bulgaria. Angewandte Parasitologie 25(2): 93-96

Noda, R., 1957: Experimental studies on Toxocara canis infections in puppies. Noda reviews the literature relating to the occurrence of post-natal infection of dogs with Toxocara canis. He fed embryonated eggs to 24 puppies (from birth to 30 days) and killed them at various intervals (1 to 40 days) after infection. He recor...

Fukase, T., 1986: Toxocara canis infections of puppies in Kanagawa Prefecture. 76 puppies aged 2-4 months in Kanagawa Prefecture, Japan, were examined for helminths between November 1984 and March 1985. 58 (76.3%) were infected with the following helminths: Spirometra erinacei (1.3%), Dipylidium caninum (17.1%), Taenia pisif...

Matsumura, K.; Endo, R., 1982: Investigation of antibodies against Toxocara canis in naturally infected puppies. A investigation of antibodies against Toxocara canis was carried out in 15 naturally infected puppies by enzyme-linked immunosorbent assay. For this, four different antigens --eggs containing second stage larvae, larvae, adult worms and excretory-...