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Control of follicular maturation in the mouse by a nonsteroidal regulator from sheep follicular fluid

Control of follicular maturation in the mouse by a nonsteroidal regulator from sheep follicular fluid

International Journal of Fertility 33(1): 52-59

Follicular fluid from sheep ovaries was subjected to gel-chromatography on Sephadex G-100, and the retarded active fraction (Fr-IV, Kav = 1) was rechromatographed on G-25 to yield 3 fractions GF1, GF2 and GF3. When injected into pseudopregnant mice, GF2 did not affect corpus luteum function, but at the end of pseudopregnancy, the expected ovulation was suppressed. Injection of 20 micro g GF2 into cycling mice inhibited follicular maturation and ovulation.

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Accession: 001554521

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PMID: 2896175

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