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Controlled trial of gamma linolenic acid in Dukes's C colorectal cancer



Controlled trial of gamma linolenic acid in Dukes's C colorectal cancer



British Medical Journal 294(6582): 1260



Two groups of 25 and 24 patients 45 to 81 years old with Dukes's C colorectal cancer were given 6 Efamol capsules daily, supplying vitamin E 60 mg and gamma -linolenic acid, an oil extract of evening primrose (Oenothera lamarckiana) seed, 3 g daily from within 1 month after operation, or a placebo. In the treated group 10 and in the control group 12 patients died with median survival 12 months in both groups. With a median follow-up of 20 and 22 months in the 2 groups, respectively, 27 patients survived. It was concluded that gamma -linolenic acid was of no benefit in colorectal cancer.

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Accession: 001554994

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PMID: 3036291



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