+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Controlled trial of long term oral potassium supplements in patients with mild hypertension

Controlled trial of long term oral potassium supplements in patients with mild hypertension

British Medical Journal 294(6585): 1453-1456

A 15 week randomised double blind placebo controlled trial of oral potassium supplements (48 mmol daily) was conducted in 37 patients who had mildly increased blood pressure and a normal dietary intake of sodium. After a two month run in and a one week baseline period the patients were randomly assigned to receive either potassium supplements (n=18) or placebo (n=19). By the third week of treatment blood pressure in the actively treated group had decreased significantly compared with that in the placebo group, though the decrease reached its maximum after 15 weeks. Urinary potassium excretion increased significantly in the group who received potassium supplements, but no significant changes were found in plasma sodium and potassium concentrations or in urinary sodium excretion. In a subgroup of 13 patients who underwent a further nine weeks of treatment with oral potassium supplements at half of the previous dose (24 mmol daily) their blood pressure, at the end of this second study period, was still significantly lower compared with their baseline value but not with that of the placebo group. These results show that moderate oral potassium supplements are associated with a long term reduction in blood pressure in patients who have mild hypertension.(author)

(PDF emailed within 0-6 h: $19.90)

Accession: 001554995

Download citation: RISBibTeXText

PMID: 3300841

DOI: 10.1136/bmj.295.6604.961-a

Related references

Placebo-controlled trial of potassium supplements in black patients with mild essential hypertension. Journal of Cardiovascular Pharmacology 14(2): 294-296, 1989

Placebo controlled trial of oral potassium in the treatment of mild hypertension. Clinical Research 34(2): 487A, 1986

Randomized placebo controlled trial of oral potassium in mild essential hypertension. Kidney International 29(1): 259, 1986

Effects of long-term oral carvedilol on the steady-state pharmacokinetics of oral digoxin in patients with mild to moderate hypertension. PharmacoTherapy 14(5): 600-606, 1994

Controlled trial of long-term oral calcium supplementation in essential hypertension. Hypertension 8(11): 1084-1088, 1986

Variations of plasma potassium concentrations during long-term treatment of hypertension with diuretics without potassium supplements. British Medical Journal 284(6317): 711-715, 1982

Short-term and long-term asthma control in patients with mild persistent asthma receiving montelukast or fluticasone: a randomized controlled trial. American Journal of Medicine 118(6): 649-657, 2005

Randomised controlled trial of treatment for mild hypertension: design and pilot trial. Report of Medical Research Council Working Party on Mild to Moderate Hypertension. British Medical Journal 1(6074): 1437-1440, 1977

Potassium supplements during long-term thiazide therapy for essential hypertension. British Journal of Clinical Pharmacology 14(2): 282-283, 1982

Double-blind, placebo-controlled trial of potassium chloride in the treatment of mild hypertension. Hypertension 9(5): 444-450, 1987

Is a controlled trial of long-term oral anticoagulants in patients with stroke and non-rheumatic atrial fibrillation worthwhile?. Lancet 1(8484): 788-792, 1986

Long-term monotherapy with drugs from four main groups of antihypertensive compounds in patients with mild and moderate arterial hypertension Multicenter trial Captopril and the Quality of Life. Terapevticheskii Arkhiv 67(6): 15-20, 1995

Betamethasone valerate aerosol in asthmatic patients receiving long-term oral steroid therapy: double-blind controlled trial and follow-up of patients for 20 months. Postgraduate Medical Journal 50 Suppl 4: 15-17, 1974

Rationale, methodology, and implementation of a nationwide multicenter randomized controlled trial of long-term mild hypothermia for severe traumatic brain injury (the LTH-1 trial). Contemporary Clinical Trials 40(): 9-14, 2015

An open multicenter study to assess the long-term efficacy, tolerance, and safety of the oral angiotensin converting enzyme inhibitor ramipril in patients with mild to moderate essential hypertension. Journal of Cardiovascular Pharmacology 13 Suppl 3: S70-S74, 1989