+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Controlled trial of zinc supplementation during recovery from malnutrition: effects on growth and immune function

Controlled trial of zinc supplementation during recovery from malnutrition: effects on growth and immune function

American Journal of Clinical Nutrition 45(3): 602-608

To evaluate the effect of zinc on growth and immune function, 32 marasmic infants were selected on admission to the nutrition recovery center; 16 received 2 mg/kg daily of elemental zinc supplement as acetate and the remaining received a placebo. Immunity was assessed by skin-test response, T-cell blastic proliferation immunoglobulins, and infectious morbidity. Weight-for-length gain for initial 60 days in Zn-supplemented group was 9% of standard vs 3% for placebo (p less than 0.05). Energy intake was similar in both groups. Incidence of infections, especially pyoderma, was significantly higher in placebo group: 10 of 16 vs 3 of 16 in the supplemented group (p less than 0.025). Plasma Zn was correlated with number of febrile days in the prospective month (r = -0.66, p less than 0.05). The percent anergic infants decreased and serum IgA increased significantly only in Zn-supplemented group. Zinc supplementation has significant effects on weight gain and host defense mechanisms despite normal plasma levels. Zinc supplementation is recommended for optimal recovery from marasmus.(author)

(PDF emailed within 0-6 h: $19.90)

Accession: 001554997

Download citation: RISBibTeXText

PMID: 3103416

DOI: 10.1093/ajcn/45.3.602

Related references

Controlled trial of copper supplementation during the recovery from marasmus Protein-energy malnutrition. American journal of clinical nutrition 37(6): 898-903, 1983

Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: a randomised placebo controlled trial. Lancet 357(9262): 1080-1085, 2001

A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. American Journal of Clinical Nutrition 80(3): 729-736, 2004

Effects of Zinc and Selenium Supplementation on Thyroid Function in Overweight and Obese Hypothyroid Female Patients: A Randomized Double-Blind Controlled Trial. Journal of the American College of Nutrition 34(5): 391-399, 2016

Effects of oral supplementation with cystine and theanine on the immune function of athletes in endurance exercise: randomized, double-blind, placebo-controlled trial. Bioscience, Biotechnology, and Biochemistry 73(4): 817-821, 2009

Short-term zinc supplementation with dispersible tablets or zinc sulfate solution yields similar positive effects on plasma zinc concentration of young children in Burkina Faso: a randomized controlled trial. Journal of Pediatrics 160(1): 129-35.E3, 2012

Growth and immune function in Aboriginal children during recovery from malnutrition and infection. Australian and New Zealand Journal of Medicine 6(4): 321-328, 1976

Randomized controlled trial of prenatal zinc supplementation and fetal bone growth. American Journal of Clinical Nutrition 79(5): 826-830, 2004

Effects of vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation on muscle function and oxidative stress biomarkers in patients with facioscapulohumeral dystrophy: a double-blind randomized controlled clinical trial. Free Radical Biology & Medicine 81: 158-169, 2015

Controlled trial of zinc supplementation on growth and body composition in Chilean children from low income groups. Pediatric Research 51(4 Part 2): 188A, April, 2002

Effects of zinc supplementation on subscales of anorexia in children: A randomized controlled trial. Pakistan Journal of Medical Sciences 30(6): 1213-1217, 2015

Zinc supplementation improved length growth only in anemic infants in a multi-country trial of iron and zinc supplementation in South-East Asia. Journal of Nutrition 138(10): 1969-1975, 2008

Exercise-induced changes in immune function: effects of zinc supplementation. Journal of Applied Physiology 76(6): 2298-2303, 1994

The impact of zinc supplementation on growth and body composition: a randomized, controlled trial among rural Zimbabwean schoolchildren. European Journal of Clinical Nutrition 51(1): 38-45, 1997

Effects of zinc supplementation on obesity: study protocol for a randomized controlled clinical trial. Trials 17(1): 534-534, 2016