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Culture of hepatic forms of Plasmodium ovale



Culture of hepatic forms of Plasmodium ovale



Bulletin de la Societe Francaise de Parasitologie 4(2): 155-163



Human and mouse hepatocyte cultures and a clone of human hepatoma Hep G2 were inoculated with sporozoites of P. ovale (Nigerian strain I/CDC) raised in Anopheles gambiae, A. stephensi and A. dirus. The sporozoites penetrated and transformed into trophozoites in all 3 cell cultures but maturation occurred only in human hepatocytes. Trophozoites were observed 26 h after penetration and became multinucleate from day 4.

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Accession: 001557296

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