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Effect of mebendazole and metronidazole on the survival of hydatid protoscolices of Echinococcus granulosus in vitro and in vivo



Effect of mebendazole and metronidazole on the survival of hydatid protoscolices of Echinococcus granulosus in vitro and in vivo



Journal of the Faculty of Medicine, Baghdad 26(4): 33-44



The inhibition by metronidazole of survival of unilocular hydatid protoscoleces was similar to that of mebendazole. In vitro, either drug at 10 micro g/ml hydatid fluid (from sheep hydatid cysts) showed scolicidal action within 48 h and all scoleces were dead on day 5 of incubation, as compared to day 12 in saline controls.

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