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Effect of thyroid hormone on turnover of tissue proteins in rats


Nutrition Reports International 35(2): 393-404
Effect of thyroid hormone on turnover of tissue proteins in rats
Effect of thyroid hormone on turnover rate of tissue proteins were investigated. Tissue proteins were labeled with 14C-sodium carbonate and the difference in the decrease of total radioactivities was compared. The rate of decrease in total radioactivity of liver proteins of rats given triiodothyronine was significantly higher than that of rats fed a diet supplemented with PTU (6-propyl-2-thiouracil, thyroid inhibitor). The decay rate in total radioactivity of kidney proteins decreased in rats administered triiodothyronine. There was no significant difference between two groups in the rate of disappearance in total radioactivity of small intestinal proteins. The decay rate in total radioactivity of liver proteins of rats fed the 20% casein diet supplemented with PTU decreased as compared with that of rats fed the 20% casein diet. The activities of cathepsin B and cathepsin D were elevated in rats treated triiodothyronine. Present results indicate that the protein degradation rate of liver is increased by the treatment of thyroid hormone. On the other hand, it was suggested that the administration of thyroid hormone to rats might decrease protein degradation rate of kidney.

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Accession: 001578214



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